Mahnaz Mahmoudi Rad
Volume 20, Issue 5 , 2018, Pages 1-1
Abstract
This corrigendum/addendum supplies corrected statements and proofs of an error by the author. The corrected au-thors list and affiliations are listed below:Fereshteh Talebpour Amiri 1,2; Fatemeh Fadaei Fathabadi 1; Mahnaz Mahmoudi Rad 3,*; Abbas Piryae 1; Maryam Ghasemi4; Alireza Khalilian 5; Farshid ...
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This corrigendum/addendum supplies corrected statements and proofs of an error by the author. The corrected au-thors list and affiliations are listed below:Fereshteh Talebpour Amiri 1,2; Fatemeh Fadaei Fathabadi 1; Mahnaz Mahmoudi Rad 3,*; Abbas Piryae 1; Maryam Ghasemi4; Alireza Khalilian 5; Farshid Yeganeh 6; Nariman Mosaffa 6
Research articles
Mahnaz Yadollahi; Asieh Mahmoudi; Mohammadhadi Niakan; Maryam Fadaei Dashti
Volume 20, Issue 5 , 2018, Pages 1-7
Abstract
Background: Trauma is the main cause of death in all age groups, as well as the 7th leading cause of fatality among the elderly. Compared to the youth, the risk of mortality and length of hospital stay are higher in elderly patients experiencing similar trauma and injury severity. Objectives: The present ...
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Background: Trauma is the main cause of death in all age groups, as well as the 7th leading cause of fatality among the elderly. Compared to the youth, the risk of mortality and length of hospital stay are higher in elderly patients experiencing similar trauma and injury severity. Objectives: The present study aimed to identify the risk factors for mortality in the elderly. Methods: This was a cross-sectional study conducted on 65304 trauma patients who were referred to Shahid Rajaee (Emtiaz) Hos- pital trauma referral center, Shiraz, Iran 2011 - 2016. Information such as age, gender, injured body region, length of hospital stay, injury severity score (ISS), injury mechanism, nosocomial infection, and mortality was recorded. Injury severity scores and injured body regions were determined based on a conversion of international classification of diseases, the 10th revision (ICD-10) injury codes to Abbreviated Injury Scale (AIS-98) severity codes using a domestically developed electronic algorithm. The binary logistic regression was used to determine the partial effects of independent risk factors. Results: Patients over 60 had a mean age of 70.79 ± 8.83. Mortality rates were 4.7% (330) and 1.05% (614) among patients over and under 60, respectively. The most important risk factors for geriatric mortality included age over 75 [OR = 1.91, 95% CI (1.28 - 2.85)], nosocomial infection [OR = 10.56, 95% CI (6.52 - 17.10)], ISS (16 - 24) [OR = 12.51, 95% CI (7.28 - 21.490)], head injury [OR = 13.17, 95% CI (5.83 - 29.77)], and pedestrian accidents [OR = 1.47, 95% CI (1.47 - 1.95)]. Aging led to increased mortality due to nosocomial infection. Among the elderly patients, males had a higher mean injury severity score compared to females. Conclusions: According to our results, mortality rates increased by age in geriatric trauma patients. With similar severity of in- juries, there was a greater risk of mortality for trauma patients with very old age compared to old patients. Aging, gender (males), nosocomial infection, ISS, and head injury were the most significant predictors of mortality in the elderly.
Morteza Mojahedi; Abbas Alipour; Roshanak Saghebi; Seyyed Ali Mozaffarpur
Volume 20, Issue 5 , 2018, Pages 1-4
Abstract
Background: As personalized medicine is developing, similar concepts in Persian medicine need standardization.Objectives: The aim of this study was to compare the correlation of ten criteria of Mizaj assessment with Mizaj determined by experts. Methods: In this cross-sectional methodological research, ...
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Background: As personalized medicine is developing, similar concepts in Persian medicine need standardization.Objectives: The aim of this study was to compare the correlation of ten criteria of Mizaj assessment with Mizaj determined by experts. Methods: In this cross-sectional methodological research, 74 medical student volunteers were examined by ten expert raters. The agreement between every ten indices and total Mizaj were assessed with the Spearman’s correlation coefficient (r) and weighted by the Kappa coefficient (wk). Results: Among ten indices, the largest agreement was observed amongst indices of psychic function, impressibility, physical func- tion and physique with total warm or cold Mizaj and thus amongst indices of muscle and fat mass, touch, and physique with totalwet or dry Mizaj, respectively (k ≥ 0.4). Conclusions: The four mentioned indices in assessing warmness-coldness and three in wetness-dryness are major criteria. Other indices, such as hair condition, skin color, quality of waste matter (stool, urine, and sweat), and sleep/wakefulness have a minor effect in Mizaj identification.
Research articles
Saeid Kashani; Hashem Jarineshin; Fereydoon Fekrat; Maryam Moradi Shahdadi; Neda Soltani Shahabadi
Volume 20, Issue 5 , 2018, Pages 1-11
Abstract
Background: The prevalence of ventricular fibrillation after removal of the aortic cross - clamp in patients undergoing coronary artery bypass surgery is about 74% - 96%. Defibrillation shock and different types of agents are used to treat ventricular fibrillation (VF). Objectives: This study was aimed ...
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Background: The prevalence of ventricular fibrillation after removal of the aortic cross - clamp in patients undergoing coronary artery bypass surgery is about 74% - 96%. Defibrillation shock and different types of agents are used to treat ventricular fibrillation (VF). Objectives: This study was aimed to compare the effects of combining Lidocaine + Magnesium Sulfate with Amiodarone + Magne- sium Sulfate in the prevention of reperfusion - induced ventricular fibrillation.Methods: This randomized, double- blinded clinical study included 74 ASA class II and III patients undergoing coronary artery by- pass grafting (CABG) in a university - affiliated hospital, Bandar Abbas, Iran, in the years 2015 - 2016. Patients were divided into two groups based on a random sample table of the lock. Both groups received Magnesium Sulfate through the cardiopulmonary bypass pump. Lidocaine 2% (100 mg) and Amiodarone (300 mg) were injected respectively to group Lidocaine + Magnesium Sulfate (LM) and group Amiodarone + Magnesium Sulfate (AM) patients before aortic cross - clamp release. The incidences of arrhythmias were recorded within 30 minutes after release of the aortic cross - clamp (ACC). Additionally, the defibrillation shocks (frequency and level of Joules delivered), amount of inotrope agent, and the hemodynamic and arterial blood gas parameters were recorded up to 24 hours postoperatively.Results: There was no significant difference between the two groups in terms of demographic characteristics, ejection fraction, and ASA class. The prevalence of ventricular fibrillation (VF) and atrial fibrillation (Af) 30 minutes after ACC release were 46.7% and 53.3% (P = 0.240) vs. 33.3% and 66.7% (P > 0.999); while, up to 24 hours post - operatively were 60% and 20.0% vs. 0.0% and 0.0% in groups LM and AM respectively. The number of defibrillations in the Lidocaine + Magnesium Sulfate group was significantly higher; 57.9% vs. 25% in groups LM and AM respectively (P = 0.004).Conclusions: The use of Amiodarone + Magnesium Sulfate reduces the number of defibrillation following the release of the Aortic cross - clamp compared with Lidocaine + Magnesium Sulfate.
Editorial
Serdar Kalemci; Aydın Sarihan; Yelda Dere
Volume 20, Issue 5 , 2018, Pages 1-3
Research articles
Maryam Eghbali-Babadi; Awat Feizi; Alireza Khosravi; Nizal Sarrafzadegan
Volume 20, Issue 5 , 2018, Pages 1-10
Abstract
Background: Patients have a significant role in controlling and treating hypertension. Improving patients’ Knowledge, Attitude, and Practice (KAP) is a crucial step in controlling hypertension. Objectives: This study aimed to examine the effect of training based on the Expanded Chronic Care Model ...
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Background: Patients have a significant role in controlling and treating hypertension. Improving patients’ Knowledge, Attitude, and Practice (KAP) is a crucial step in controlling hypertension. Objectives: This study aimed to examine the effect of training based on the Expanded Chronic Care Model (ECCM) on KAP in patients with hypertension residing in Isfahan, Iran. Methods: The clinical trial was conducted on 190 hypertensive patients aged 36 to 80 in 2015 - 2016. Patients were randomly assigned to an intervention and a control group. The intervention plan based on ECCM was four 2-hour education sessions for the intervention group and a family member. Then, follow-ups were done by a phone call for six months. Meanwhile; there was no intervention in the control group. The data collection was done using KAP (a valid researcher-made questionnaire), before and after intervention in both groups. Results: In the intervention group, there was a statistically significant difference between the mean score of KAP before and six months after the ECCM training (P < 0.05). No significant differences were observed in the control group. The two groups were notsignificantly different in terms of the Mean ± SD of KAP scores before the intervention. Six months after implementing the care model, however, the Mean ± SD of KAP scores were significantly higher in the intervention group compared to in the controls (P < 0.05). Conclusions: Based on the results, a training program based on the ECCM is effective in improving the knowledge, attitude, and practice of patients. The ECCM could therefore be used as a framework for designing educational interventions for patients with hypertension
Research articles
Hajar Mardani Valandani; Naser Amirizadeh; Mahin Nikougoftar; Majid Safa; Roohollah Mirzaee Khalilabadi; Ahmad Kazemi
Volume 20, Issue 5 , 2018, Pages 1-8
Abstract
Background: Several studies show that mesenchymal stem cells (MSCs) possess anti-tumor properties, while other studies show that MSCs may promote cancer. Extracellular vesicles (EVs) are identified as novel mediators to communicate among cells, which may be used as vehicles to transfer the MSC information ...
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Background: Several studies show that mesenchymal stem cells (MSCs) possess anti-tumor properties, while other studies show that MSCs may promote cancer. Extracellular vesicles (EVs) are identified as novel mediators to communicate among cells, which may be used as vehicles to transfer the MSC information to the target cells. Objectives: The current study aimed at investigating whether the human umbilical cord mesenchymal stem cell (HUSCMSC) de- rived extracellular vesicles (EVs) inhibits or promotes tumor cell growth in K562 chronic myelogenous leukemia cell line.Methods: In the current experimental study, trypan blue exclusion and 3-(4, 5-dimethylthiazol-2-yl)-2, 5 diphenyltetrazolium bro- mide (MTT) assay were performed to investigate the cell viability and metabolic activity. Additionally, flow cytometry was employed to assess cell cycle and apoptosis of K562 cells after 72 hours exposure to EVs. Results: The obtained results showed that no doses of EVs inhibited the tumor growth (mean ± standard deviation (SD) of cell viability at the day 10 was 94.4 ± 2.60, P > 0.05) and metabolic activity in three days (mean ± SD at the day 3 was 97.27 ± 2.46, P > 0.05). Furthermore, EVs also did not change the apoptosis rate (mean ± SD at the day 3 was 3.17 ± 2.34 for annexin positive cells, and 3.36 ± 1.91 for annexin/propidium iodide (PI) -positive cells, P > 0.05).Conclusions: In conclusion, no significant changes in tumor cell growth were observed after treating K562 cells with MSCs-derived EVs.
Research articles
Lu-yun Qu; Hai-yang Jiang; Jing Wang; Zeng-hui Li; Xiao-hong Li; Jian-qing Hou
Volume 20, Issue 5 , 2018, Pages 1-7
Abstract
Background: Ovarian Cancer is one of the most fatal female neoplasms associated with high mortality. Finding of the new mecha- nisms involved in the development of ovarian cancer will help us to better diagnosis and effective treatment.Objectives: The current bioinformatics study aimed at investigating ...
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Background: Ovarian Cancer is one of the most fatal female neoplasms associated with high mortality. Finding of the new mecha- nisms involved in the development of ovarian cancer will help us to better diagnosis and effective treatment.Objectives: The current bioinformatics study aimed at investigating the relationship between messenger RNA (mRNA) and long non-coding RNA (lncRNA) in ovarian cancer through the LncRNAs2Pathways method. Methods: The genome-wide lncRNA and mRNA data obtained from 185 ovarian cancer and healthy control samples originated fromMichigan Medical School were downloaded and pretreated from European bioinformatics institute (EMBL-EBI) database. The inter- actions between miRNA and mRNA, and the intersections between lncRNA and miRNA were identified with starBase version 2.0. A long non-coding RNA-mediated ceRNA network (LMCN) was constructed by integrating lncRNA-mRNA and lncRNA-mRNA intersec- tions. Then, the lncRNAs were mapped to the network, and these lncRNAs were regarded as source nodes, and the random walk with restart (RWR) algorithm was also applied to evaluate the effect of source nodes on protein-coding genes. Finally, the Kolmogorov- Smirnov-like statistics weighted by the propagation score was used to evaluate the enrichment value of each functional pathway. Results: After preliminary screening, the gene expression profile including 12,437 genes was obtained. The LMCN network includ- ing 11 lncRNA and 367 mRNA were identified. A total of 11 differentially expressed lncRNAs between the normal and ovarian cancersamples by the LCMN network were identified. The LncRNAs2Pathways screened six functional pathways (P < 0.05) coregulated by lncRNAs related to ovarian cancer. Conclusions: A total of six functional pathways related to lncRNA and mRNA interactions in ovarian cancer were identified. This finding is beneficial for effective diagnosis of patients with ovarian cancer, and also provides a new insight into the treatment of this disease.
Research articles
Sara Sayar; Rahim Tahmasebi; Parviz Azodi; Tahereh Tamimi; Faezeh Jahanpour
Volume 20, Issue 5 , 2018, Pages 1-7
Abstract
Background: Clinical Decision Making (CDM) is the foremost aspect of caring for patients. Storytelling can enhance skills such as judging, and problem-solving among people, especially in clinical education environments. Objectives: The current study aimed at investigating the impact of tacit knowledge ...
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Background: Clinical Decision Making (CDM) is the foremost aspect of caring for patients. Storytelling can enhance skills such as judging, and problem-solving among people, especially in clinical education environments. Objectives: The current study aimed at investigating the impact of tacit knowledge transfer through storytelling on CDM by nurses.Methods: The current quasi-experimental study was conducted on 61 nurses. The participants were selected by convenience sam- pling method and randomly assigned into experimental and control groups. An eight-hour storytelling session was held for the experimental group, but not for the control group. The assessment tool was the Jenkins’ CDM in nursing scale. Results: The mean scores of CDM pre-intervention were 146.80 ± 12.68 and 138.42 ± 12.64 in the experimental and control groups, respectively (P = 0.012). The mean scores of CDM post-intervention were 163.43 ± 18.45 and 139.10 ± 11.78 for the experimental and control groups, respectively (P < 0.001). The gain scores were 28.74 ± 38.90 and 0.78 ± 3.84 in the intervention and control groups, respectively. The difference was statistically significant (P < 0.001). Conclusions: The obtained results showed that the transfer of knowledge and experiences through storytelling significantly en- hanced CDM score
Research articles
Ali Sadeghpour Tabaei; Meysam Mortazian; Alireza Yaghoubi; Farhad Gorjipour; Shaghayegh Arasteh Manesh; Ziae Totonchi; Bahador Baharestani; Mohammadjavad Mehrabanian; Hamidreza Pazoki-Toroudi; Hossein Kaveh; Yaser Toloueitabar; Ameneh Ghanbari; Fazel Gorjipour
Volume 20, Issue 5 , 2018, Pages 1-10
Abstract
Background: Modified Ultrafiltration (MUF) has been used in Cardiopulmonary Bypass (CPB) operations to prevent hemodilution and remove pro-inflammatory cytokines. It has been studied in pediatric operation settings. However, evidence exists regarding its application in adults’ Coronary Artery Bypass ...
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Background: Modified Ultrafiltration (MUF) has been used in Cardiopulmonary Bypass (CPB) operations to prevent hemodilution and remove pro-inflammatory cytokines. It has been studied in pediatric operation settings. However, evidence exists regarding its application in adults’ Coronary Artery Bypass Grafting (CABG) operation.Objectives: The present study investigated MUF and its effects on inflammatory cytokine response, hemodilution and rotational thromboelastometry outcomes in adults’ CABG operation. Methods: In a randomized controlled trial, 56 elective CABG patients that had referred to the Rajaie Cardiovascular Medical andResearch Center (Tehran, Iran) during year 2017 were randomly assigned to two groups, including control and MUF groups. Pre- operative and postoperative clinical parameters were recorded. Serum level of inflammatory cytokines after clamp removal, af- ter Cardiopulmonary Bypass (CPB) (MUF in the MUF group) and 24 hours after Intensive Care Unit (ICU) entrance, and Rotational Thrombo-elastometry (ROTEM) indices, pre-operation, and post-operation, were measured. Results: The two groups were similar in clinical perioperative parameters, including hemodynamics, transfusions, ROTEM indices, mechanical ventilation and CPB time, and ICU stay. The levels of inflammatory mediators were significantly increased after CPB in both groups. Interleukin (IL)-6, -8 and -10 measures were equal between the two groups in all trial measurement points. The MUF group demonstrated a significantly lower level of Tumor Necrosis Factor (TNF)-α compared with the control group after CPB (1.55 ± 0.29 versus 1.77 ± 0.35 log10 pg/mL, respectively; P = 0.031). Hemoglobin (9.55 ± 0.96 versus 8.29 ± 0.57 g/dl, P < 0.001) and hematocrit % (29.96 ± 3.23 and 24.72 ± 1.62, P < 0.001) levels were significantly higher in the MUF group compared with the control, after CPB.Conclusions: Modified Ultrafiltration eliminates extra liquids and TNF-α from circulation in adults CABG operation, without affect- ing the hemostatic indices and improves hemoglobin level. It does not remove anti-inflammatory cytokine IL-10 from circulation.
Letter to Editor
Saeed Sardari; Faramarz Fallahi; Fatemeh Emadi; Narjes Khavasi; Seied Saeid Esmaeili
Volume 20, Issue 5 , 2018, Pages 1-2
Research articles
Arezoo Moini Jazani; Hossein Nazemiyeh; Mojgan Tansaz; Homayoun Sadeghi Bazargani; Seyed Mohammad Bagher Fazljou; Ramin Nasimi Doost Azgomi; Kobra Hamdi
Volume 20, Issue 5 , 2018, Pages 1-11
Abstract
Background: Polycystic ovary syndrome (PCOS)-induced oligomenorrhea can leave psychological and non-psychological impacts on women. Among the proposed strategies for its treatment, herbal medications are of importance due to favorable effect profiles. Objectives: We planned a study to compare the effects ...
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Background: Polycystic ovary syndrome (PCOS)-induced oligomenorrhea can leave psychological and non-psychological impacts on women. Among the proposed strategies for its treatment, herbal medications are of importance due to favorable effect profiles. Objectives: We planned a study to compare the effects of Celery and Anise combination (CAC) and metformin (met.) on oligomen- orrhea in PCOS patients. Methods: We conducted a triple-blind, Randomized clinical trial on 72 patients that were randomly allocated into two equal groups to receive six capsules of either CAC (750 mg each) or met. (250 mg each) at three separate doses for 15 days beginning from the follic- ular phase. If the bleeding occurred, three capsules of either placebo or met. would be administered daily during the menstruation phase, and then the follicular phase step with six capsules would be repeated. If the bleeding did not occur, three capsules of eitherplacebo or met. would be administered each day for 15 days. The regularity of menstrual bleeding as the primary outcome, as well as testosterone, luteinizing hormone/follicular stimulating hormone ratio (LH/FSH), and complications, was assessed before and after the three cycles. Results: The mean age ± standard deviation of patients was 26.5 ± 6.1. The mean Body Mass Index was 26.4 ± 3.5. CAC significantly improved oligomenorrhea (58.3% vs. 25%, P < 0.01), increased bleeding episodes (P = 0.003), and reduced testosterone (mean dif- ference: 0.16 vs. -0.02, P = 0.005) and LH/FSH (mean difference: 0.75 vs. -0.08, P = 0.002) without any major side effects compared to met.Conclusions: We showed that Celery and Anise combination could regulate menstrual cycles and improve oligomenorrhea in poly- cystic ovary syndrome patients superiorly to metformin.
