Relationship between Creatine Kinase and Major Bleeding in Patients with Non-ST-segment Elevation Acute Coronary Syndrome


Creatine kinase
Major bleeding
Non-ST-segment elevation acute coronary syndrome

How to Cite

Zhang, J., Shao, K., Yang, S., & Ma, Q. (2021). Relationship between Creatine Kinase and Major Bleeding in Patients with Non-ST-segment Elevation Acute Coronary Syndrome. Iranian Red Crescent Medical Journal, 23(9).


Background: The present study aimed to investigate the relationship between creatine kinase (CK) and major bleeding in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) during hospitalization.

Objectives: The predictive value of CK was also analyzed for the patients during treatment.

Methods: A total of 1469 patients with NSTE-ACS, including 1024 and 445 patients with unstable angina pectoris and non-ST-segment elevation myocardial infarction, respectively, were admitted to Linyi Central Hospital, Linyi, China from January 2017 to December 2019. Plasma CK and hemoglobin concentrations were measured after admission. The patients were divided into the major bleeding (n=31) and non-major bleeding (n=1438) groups according to Thrombolysis in Myocardial Ischemia bleeding classification standard, and they received routine treatment.

Results: Major bleeding occurred in 31 of 1469 (2.11%) patients with NSTE-ACS during the treatment period. The value of CK in the major bleeding group was higher than that of the non-major bleeding group (P<0.001). CK was divided into groups Q1- Q4 according to the quartile, and the incidence of major bleeding was higher in group Q4 than that of the other three groups (P<0.001). Plasma CK was positively correlated with major bleeding in patients with NSTE-ACS (r=0.59, P<0.001). Receiver operating characteristic curve analysis indicated that the area below the curve of baseline CK value was 0.793 (SE=0.062, P=0.001, 95%CI 0.711-0.872) in patients with NSTE-ACS during treatment.

Conclusion: CK was associated with major bleeding in patients with NSTE-ACS.


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