Effective Reduction of Inflammatory and Coagulation Factors using Sitagliptin in Type 2 Diabetes
Vol. 23 No. 3 (2021), Research articles
Vol. 23 No. 3 (2021)

Effective Reduction of Inflammatory and Coagulation Factors using Sitagliptin in Type 2 Diabetes

Research articles
https://doi.org/10.32592/ircmj.2021.23.3.324
Published 2021-03-27
Maryam Ghavami
Department of Internal Medicine, Endocrinology Division, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Jalil Houshyar
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Amir Mehdizadeh
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mostafa Najafipour
1. Young Researchers and Elite Club, Ardabil Branch, Islamic Azad University, Ardabil, Iran 2. Department of Internal Medicine, Faculty of Medicine, Ardabil Azad University of
Farzad Najafipour
1. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2. Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords

Fibrinogen
hs-CRP
Pioglitazone
Sitagliptin
Type 2 diabetes

How to Cite

Ghavami, M. ., Houshyar, J., Mehdizadeh, A. ., Najafipour, M. ., & Najafipour, F. (2021). Effective Reduction of Inflammatory and Coagulation Factors using Sitagliptin in Type 2 Diabetes . Iranian Red Crescent Medical Journal, 23(3). https://doi.org/10.32592/ircmj.2021.23.3.324
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Abstract

Introduction: There are different drug-based treatments (i.e., oral or injective) for patients with type 2 diabetes. Pioglitazone and sitagliptin, among oral agents, can affect blood glucose control and lipid profile.

Objectives: The purpose of the current investigation was the assessment of the effects of adding sitagliptin or pioglitazone (as the third drug) to the combined metformin-sulfonylurea treatment on glycemic control, inflammatory factors, and lipid profile.

Methods: This clinical trial was carried out on 125 patients with type 2 diabetes undergoing metformin-glibenclamide treatment. The patients were randomly divided into three groups, namely the sitagliptin group receiving 100 mg of sitagliptin for 3 months (n=45), pioglitazone group receiving 30 mg of pioglitazone for 3 months (n=40), and control group (n=40). After the interventions, the anthropometric indices, glycated hemoglobin A1c level, lipid profile, fibrinogen, and high-sensitivity C-reactive protein (hs-CRP) were compared among the study groups.

Results: The sitagliptin group demonstrated significantly lower levels of hs-CRP (0.53±0.26 mg/L) and fibrinogen (314.08±48.09 mg/dL), compared to those reported for the pioglitazone and control groups. In contrast, significantly lower triglyceride levels (115.02±32.92 mg/dL) and significantly higher high-density lipoprotein cholesterol (51.57±11.14 mg/dL) were observed in the pioglitazone group in comparison to those reported for the sitagliptin and control groups.

Conclusion: The results of the present study suggest that sitagliptin reduces the levels of fibrinogen and hs-CRP. Nevertheless, pioglitazone has a more significant effect on the improvement of the lipid profile, compared to sitagliptin and combined metformin-sulfonylurea treatments.

 

https://doi.org/10.32592/ircmj.2021.23.3.324
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