Extensive Bowel Necrosis in a Case of COVID-19 Disease Despite Warfarin Toxicity: A Paradoxical Event


ACE-2 receptors
Bowel necrosis
Warfarin toxicity


How to Cite

Sarkardeh, M. ., Rezapanah, A. ., Ayati Afin, A. ., Shamshirian, A. ., Sadrzadeh, Z. ., Koushki, J. ., & Dalili, A. (2022). Extensive Bowel Necrosis in a Case of COVID-19 Disease Despite Warfarin Toxicity: A Paradoxical Event. Iranian Red Crescent Medical Journal, 24(12). https://doi.org/10.32592/ircmj.2022.24.12.2246


Background: Coronavirus disease 2019 (COVID-19) involves multiple organs, including the gastrointestinal tract. It also causes frequent thromboembolic events because of its thrombogenicity. This study reports a COVID-19 case of extensive bowel necrosis despite using warfarin.

Case Presentation: A 52-year-old homeless addict male was brought via Emergency Medical Services with a chief complaint of abdominal pain for two days and loss of consciousness since the day before. He had a history of cough and dyspnea for seven days and had been using warfarin after mitral valve replacement three years earlier. On admission, he had low oxygen saturation, tachycardia, and fever. Because of his respiratory signs and symptoms, a chest CT scan was performed, and evidence of COVID-19 infection was detected. He had nausea, and on abdominal examination, there was generalized tenderness, rebound tenderness, and guarding. Following physical examination and abnormal laboratory test results, he underwent an emergent laparotomy. Extensive necrosis made surgical intervention impossible, and he died shortly after the surgery.

Conclusion: COVID-19-associated coagulopathy raises many challenges nowadays, and according to the present case, even using anticoagulants may not prevent it.



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