Efficacy and Safety of Concurrent Chemoradiotherapy with Docetaxel for Locally Advanced Breast Carcinoma after Modified Radical Mastectomy

Keywords

Breast cancer
Modified radical mastectomy
Docetaxel
Concurrent chemoradiotherapy

Categories

How to Cite

Wang, J., Wei, C., Liu, W. ., Wang, B., & Han, Q. (2022). Efficacy and Safety of Concurrent Chemoradiotherapy with Docetaxel for Locally Advanced Breast Carcinoma after Modified Radical Mastectomy. Iranian Red Crescent Medical Journal, 24(7). Retrieved from https://ircmj.com/index.php/IRCMJ/article/view/1992

Abstract

Background: Breast cancer is a common term for a malignant tumor that arises from the epithelial component of the breast. Concurrent chemoradiotherapy’s efficacy and safety are controversial, considering the impact on patients' quality of life.
Objective: To investigate the efficacy and safety of concurrent chemoradiotherapy with docetaxel in locally advanced breast cancer who have received a modified radical mastectomy.
Methods: A cohort of 110 female patients with locally advanced breast cancer were included in the present study and divided by chemoradiotherapy mode into a concurrent chemoradiotherapy group (n=58) and a sequential chemoradiotherapy group (n=52). The two groups were compared with respect to clinical efficacy, levels of tumor markers across vascular endothelial growth factor (VEGF), and carcinoembryonic antigen (CEA).
Results: The overall response rate came at 45.83% in the concurrent group and 40.48% in the sequential group. There was no remarkable difference in VEGF and CEA levels between the two groups (P < 0.05); After treatment, the levels were significantly lower than those in the same group before treatment (P < 0.05). The median survival time was 26 months in the concurrent group and 25 months in the other group, while their 3-year survival rates varied greatly (79.17% for the concurrent VS 69.05% for the sequential) (P>0.05).
Conclusion: The chemotherapy protocol with a combination of cyclophosphamide, fluorouracil and epirubicin with concurrent docetaxel presented higher efficacy and prolonged the overall survival in locally advanced breast cancer patients who had undergone a radical mastectomy, while it did not significantly increase the toxicity.

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