Melatonin for Clinical Improvement in Patients with Ischemic Stroke: a Randomized Clinical Trial


Inflammation, Ischemic stroke, Melatonin


How to Cite

Faraji, F., Talaie Zanjani, A., Rezaie Ashtiani, A., Motamedi, G., & Nourigheimasi, S. (2023). Melatonin for Clinical Improvement in Patients with Ischemic Stroke: a Randomized Clinical Trial. Iranian Red Crescent Medical Journal, 25(2).


Introduction: Ischemic stroke is the most frequent form of the stroke which imposes a lot of cost and disabilities for patients. Melatonin is proved to have anti-oxidant along with anti-inflammatory effects. The goal of this study was to assess effects of melatonin on clinical features of acute stroke in Iranian patients.
Methods: Fifty eight patients with ischemic stroke were randomly assigned to: Group 1: ASA 80mg/day+ Plavix 75 mg/day+ melatonin 3 mg (every night one pill for two months) and Group 2: ASA 80 mg/day+ Plavix 75 mg/day+ placebo (every night one pill for two months). Canadian Neurological Stroke Scale (CNSS) was recorded for all cases before and after treatment.
Results: Mean age, sex, circulation, CVA incidence time and symptoms were not significantly different between two groups. Mean CNSS was significantly higher after treatment in both groups.
Conclusions: CNSS improved more in intervention group than control group. So, Melatonin administration in patients with ischemic stroke will result in better clinical improvement.


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