Melatonin for Clinical Improvement in Patients with Ischemic Stroke: a Randomized Clinical Trial
Vol. 25 No. 2 (2023), Research articles
Vol. 25 No. 2 (2023)

Melatonin for Clinical Improvement in Patients with Ischemic Stroke: a Randomized Clinical Trial

Research articles
https://doi.org/10.32592/ircmj.2023.25.2.1471
Published 2023-02-25
Fardin Faraji
Associate professor of Neurology, Arak University Of Medical Sciences, Arak , Iran
Afsoon Talaie Zanjani
MSC of Nutrition , Phd Of Biochemistry, MSC of nutrition, Health Department , Islamic Azad University, Arak Branch, Iran
Alireza Rezaie Ashtiani
Associate Professor of Neurology, Arak University Of Medical Sciences, Arak , Iran
Golnaz Motamedi
Doctor of Medicine , Arak University Of Medical Sciences, Arak , Iran
Shima Nourigheimasi
Medical Doctor, School of Medicine, Arak University of Medical Sciences, Arak, Iran
https://orcid.org/0000-0001-5038-8187

Keywords

Inflammation, Ischemic stroke, Melatonin

Categories

How to Cite

Faraji, F., Talaie Zanjani, A., Rezaie Ashtiani, A., Motamedi, G., & Nourigheimasi, S. (2023). Melatonin for Clinical Improvement in Patients with Ischemic Stroke: a Randomized Clinical Trial. Iranian Red Crescent Medical Journal, 25(2). https://doi.org/10.32592/ircmj.2023.25.2.1471
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Abstract

Introduction: Ischemic stroke is the most frequent form of the stroke which imposes a lot of cost and disabilities for patients. Melatonin is proved to have anti-oxidant along with anti-inflammatory effects. The goal of this study was to assess effects of melatonin on clinical features of acute stroke in Iranian patients.
Methods: Fifty eight patients with ischemic stroke were randomly assigned to: Group 1: ASA 80mg/day+ Plavix 75 mg/day+ melatonin 3 mg (every night one pill for two months) and Group 2: ASA 80 mg/day+ Plavix 75 mg/day+ placebo (every night one pill for two months). Canadian Neurological Stroke Scale (CNSS) was recorded for all cases before and after treatment.
Results: Mean age, sex, circulation, CVA incidence time and symptoms were not significantly different between two groups. Mean CNSS was significantly higher after treatment in both groups.
Conclusions: CNSS improved more in intervention group than control group. So, Melatonin administration in patients with ischemic stroke will result in better clinical improvement.

https://doi.org/10.32592/ircmj.2023.25.2.1471

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