Atraumatic Splenic Rupture as a Rare Complication of Acute Myeloid Leukemia: A Case Report and Literature Review


Acute myeloid leukemia
Atraumatic splenic rupture
Case report
Hematological diseases
Splenic rupture


How to Cite

Kalantari, M. E. ., Azadmanesh, Y. ., Bagherzadeh, A. A. ., Hoseinpour, H. ., & Zandbaf, T. (2021). Atraumatic Splenic Rupture as a Rare Complication of Acute Myeloid Leukemia: A Case Report and Literature Review. Iranian Red Crescent Medical Journal, 23(12).


Introduction: Atraumatic Splenic Rupture (ASR) is a rare but life-threatening clinicopathological phenomenon with limited information on patient features, occurrence, or etiology. ASR is an uncommon and lethal complication that is observed in infectious (mainly mononucleosis) and hematological diseases (mainly malignant homeopathies) in more than half of cases. Mortality is approximately around 20%, and some deaths occur before the diagnosis is confirmed, while others occur after surgery due to delayed management and poor patient status.

Case Presentation: A 48-year-old man with no history of the underlying disease presented to the Emergency Department with abdominal pain. He was admitted with leukocytosis 145×103/µl, hemoglobin 6.4 g/dl, platelets 15×103/µl, erythrocyte sedimentation rate 89 mm/h, and D-Dimer 1043 ng/FEU ml. Sputum test through PCR ruled out severe acute respiratory syndrome coronavirus 2 infections. Due to peripheral blood smear and bone marrow aspiration/biopsy, acute myeloid leukemia was diagnosed for the patient. On the third day of hospitalization, the patient's abdominal pain intensifies. Ultrasound revealed medium free fluid inside the abdomen and pelvis. The patient was transferred to the operating room to undergo an emergency laparotomy. There was a large hematoma in the spleen with a rupture in its posterior surface. Splenectomy was performed, and the histopathological study of the spleen showed leukemic involvement, capsular ruptures, and subcapsular hematomas.

Conclusion: ASR can occur for a variety of reasons, including non-traumatic or idiopathic factors. In the absence of significant trauma, emergency physicians should be aware that splenic rupture can occur. ASR is more likely to present with symptoms similar to the underlying diseases.


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