Aria Kasiri; Maryam Eskandari Mehrabadi; Zahra Salemi; Danial Habibi; milad majidian dehkordi; omid jarahian; rasool karimi matloob
Volume 26, Issue 1 , 2024
Abstract
Background: Coronavirus disease 2019 (COVID-19), a severe disease caused by severe acute respiratory syndrome coronavirus 2, has a weak prognosis, and biological markers may predict disease severity.
Objectives: The present study aimed to assess the impact of vitamin D levels on COVID-19 outcomes in ...
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Background: Coronavirus disease 2019 (COVID-19), a severe disease caused by severe acute respiratory syndrome coronavirus 2, has a weak prognosis, and biological markers may predict disease severity.
Objectives: The present study aimed to assess the impact of vitamin D levels on COVID-19 outcomes in diabetic people.
Methods: The study was conducted on 160 individuals with both COVID-19 and diabetes at Amir-Al-Momenin Hospital in Arak. Participants completed a questionnaire regarding their personal information, medical history, and medication use. Arterial and venous blood samples were collected after 12 hours of fasting to perform arterial blood gas (ABG) and brachial venous fasting blood glucose tests, respectively. The samples were sent to the laboratory for analysis. Serum levels of 25-hydroxyvitamin D were measured using the ELISA method. The study groups were classified based on the obtained PO2 levels from the ABG test, indicating varying degrees of respiratory impairment.
Results: Patients were categorized as mild, moderate, or severe based on ABG test results. No significant difference was found in vitamin D levels among groups. Elevated levels of vitamin D in women and men with mild and moderate COVID-19 symptoms have been linked to a decrease in mortality rate. Nonetheless, significant correlations were observed between vitamin D and fasting blood sugar (FBS) levels in the mild and moderate groups, indicating varying relationships between vitamin D and FBS across these groups.
Conclusion: While immunizations and antiviral drugs work well against COVID-19, taking extra measures, such as vitamin D supplementation, plays a vital role in disease management.
Zahra Kosarian; Mehrnoosh Zakerkish; Mohammad-Jafar Shaterzadeh-Yazdi; Saeed Hesam; Mohammad Mehravar
Volume 24, Issue 3 , 2022
Abstract
Background: Diabetes mellitus (DM) is one of the most common chronic non-communicable diseases (NCD).
Objectives: The present study aimed to investigate the relationship between demographic and clinical data with balance impairments in people with diabetic peripheral neuropathy (DPN), considering the ...
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Background: Diabetes mellitus (DM) is one of the most common chronic non-communicable diseases (NCD).
Objectives: The present study aimed to investigate the relationship between demographic and clinical data with balance impairments in people with diabetic peripheral neuropathy (DPN), considering the importance of early detection of balance impairments in this population.
Methods: Forty-three patients with DPN were evaluated in this cross-sectional study. Age, disease duration, height, weight, and physical activity, along with blood sugar samples and neuropathy disability scores were collected to explore correlations with the balance evaluation system test (BESTest) in this population.
Results: A significant weak to moderate correlations was found between physical activity (p-value=0.046/ CC= 0.286), severity of neuropathy (p-value=0.025/ CC= -0.317), and gender (p-value=0.032/ CC= -0.311) with BESTest, using multivariate linear regression analysis.
Conclusion: It is recommended that diabetic patients with a sedentary lifestyle, more severe scores on neuropathy screening instruments, and female patients be referred for early screening of balance disorders regardless of age and disease duration. Also, increasing physical activity to prevent balance impairments in the future can be recommended.
Talha Karab?y?k; Durmu? Ayan; Sercan Unal
Volume 24, Issue 3 , 2022
Abstract
Background: Hepsin is known as a cell-surface serine protease expressed predominantly in the liver. Hepsin-deficient mice show resistance to high-fat diet-induced obesity, hyperlipidemia, and hyperglycemia. Up to the present, the physiological function of hepsin has not been fully determined. Hepsin ...
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Background: Hepsin is known as a cell-surface serine protease expressed predominantly in the liver. Hepsin-deficient mice show resistance to high-fat diet-induced obesity, hyperlipidemia, and hyperglycemia. Up to the present, the physiological function of hepsin has not been fully determined. Hepsin may play significant and specific roles in diabetes.
Objectives: This study aimed to evaluate the relationship between hepsin protein concentrations in serum and type 2 diabetes mellitus (T2DM) and elucidate possible associations with disease activity andinflammatory and metabolic parameters. To the best of our knowledge, this is the first study evaluating the relationship between hepsin, lymphocyte-to-C-reactive protein ratio (LCR), and type 2 diabetes in humans in the existingliterature.
Methods: This case-control study included 60 patients (30 males and 30 females) diagnosed with type 2 diabetes, according to American Diabetes Association's criteria, and 30 healthy controls (14 males and 16 females) with similar demographic characteristics. Several laboratory parameters were assessed including fasting glucose, total cholesterol, insulin, hemoglobin A1c, gamma-glutamyl transferase, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, uric acid, C-reactive protein, atherogenic index of plasma, LCR, monocyte-to-neutrophil ratio,neutrophil-to-lymphocyte ratio, and serum hepsin levels.
Results: The type 2 diabetes group had significantly higher LCR than controls (P<0.016). Correlation analysis in the patient group showed a statistically significant relationship between hepsin and LCR (rho=0.296,P=0.02). Hepsin was negatively correlated with CRP in the patient group (rho=-0.333, P=0.01). Correlation analysis in the patient group showed a statistically significant relationship between hepsin and cholesterol (rho= 0.29,P= 0.02). Age was positively correlated with hepsin in the patient group (rho= 0.267, P=0.04). There was no statistically significant difference in serum hepsin levels between the diabetes group and the control group (P=0.157).
Conclusion: To the best of our knowledge, this is the first study assessing the hepsin levels in patients with T2DM. Our results indicated that increased levels of hepsin could be associated with the inflammatory processes. Similar results were not found for diabetes. However, it is recommended that similar studies should be conducted in larger patient populations.
sogand Ghasemzadeh; zahra naghsh
Volume 22, Issue 11 , 2020
Abstract
Background: Type I diabetes (T1DT1D) is recognized as one of the most prevalent chronic diseases in children. It is accompanied by potentially life-threatening complications which affect the mood, personality, and emotions of children and their families.
Objectives: The present study aimed ...
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Background: Type I diabetes (T1DT1D) is recognized as one of the most prevalent chronic diseases in children. It is accompanied by potentially life-threatening complications which affect the mood, personality, and emotions of children and their families.
Objectives: The present study aimed to assess the effectiveness of the unified protocols for transdiagnostic treatment program in emotion regulation of mothers and anxiety of children with T1D.
Methods: The present experimental ?study was conducted using the pretest-posttest follow-up control group design. The statistical population included all children with T1D within the age range of 9-11 years T1Dand their mothers who were referred to Iran Diabetes Association in Tehran in 2019-2020. The statistical sample was selected via the convenience (purposive) sampling method from among children with T1D and their mothers, and the subjects were randomly assigned to two experimental and control groups. The Cognitive Emotion Regulation Questionnaire (CERQ) developed by Garnefski et al. and Spence Childrens Anxiety Scale (SCAS) were completed in the pretest, posttest, and follow-up. Diabetic children and their mothers received 15 sessions of the unified protocols for transdiagnostic treatment, while no special training was provided to the control group.
Results: The results of the present study indicated that the three measurements performed in pretest, posttest, and follow-up significantly differed regarding children's anxiety and mothers' emotion regulation strategies (e.g., catastrophizing, coping and acceptance, positive thinking, and blaming others) pointing to the effectiveness of transdiagnostic treatment (P= 0.000).
Conclusion: The obtained results suggested the effectiveness of the unified protocols for transdiagnostic treatment program in reducing the anxiety of children with type 1 diabetes and improving the emotion regulation of their mothers.
Nazli Batar; Seda Kermen; Sezen Sevdin; Aybuke Ersin; Sevil San; Mustafa Genco Erdem; Halime Pulat Demir; Duygu Guclu
Volume 22, Issue 6 , 2020
Abstract
Abstract
Background: The prevalence of type 2 diabetes mellitus (T2DM) has increased dramatically in the past 30 years. The World Health Organization has prepared an action plan to stop the increase in diabetes and obesity by 2025.
Objectives: This study was conducted to assess the effect of ...
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Abstract
Background: The prevalence of type 2 diabetes mellitus (T2DM) has increased dramatically in the past 30 years. The World Health Organization has prepared an action plan to stop the increase in diabetes and obesity by 2025.
Objectives: This study was conducted to assess the effect of pilates on body composition and some biochemical parameters in women with T2DM on a high-complex-carbohydrate diabetic diet or a low-carbohydrate/high-monounsaturated fatty acids (MUFA) diet.
Methods: This experimental study was conducted on 120 woman patients with T2DM, referring to the Fatih Medical Park Hospitals
Internal Medicine Department, Istanbul, Turkey, between December 2018 and June 2019. Participants were divided into 4 groups and were followed up for 12 weeks. The mean participants age was 41.67 ± 3.83 years. The first group received a low-carbohydrate and high MUFA (LC, MUFA) diet, the second group received a low-carbohydrate and a high-MUFA diet and did pilates (LC, MUFA + PL), the third group received a higher complex carbohydrate (HCC) diet, and the fourth group took the HCC diet and did pilates (HCC + PL).
Results: According to the applied intervention method, there were significant differences between the preliminary and final mea- surements of body mass index, body fat percentage, muscle mass, and fasting blood glucose, insulin, HbA1c, total cholesterol, high- density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride (TG) values (P < 0.05). In this study, only an increase in body muscle composition of the women in the LC, MUFA + PL group was found significant (P < 0.05). The highest decrease in body fat ratio was determined again in the LC, MUFA + PL group (P < 0.05). HDL levels of the women who did pilates increased significantly than other groups (P < 0.05).
Conclusions: In the treatment of diabetes, the patient should be evaluated with a multidisciplinary team. Diet and exercise are
important non-pharmacological interventions in the treatment of diabetes.
Sevda Gholizadeh Shamasbi; Parvin Dehghan; Sakineh Mohammad-Alizadeh Charandabi; Akbar Aliasgarzadeh; Mojgan Mirghafourvand
Volume 20, Issue 11 , 2018, Pages 1-9
Abstract
Background: Polycystic Ovary Syndrome (PCOS) increases the risk of cardiovascular diseases and diabetes, and obesity can acceler- ate this trend. Objectives: This study aimed at determining the effect of prebiotics on anthropometric indices in patients with this syndrome. Methods: This controlled clinical ...
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Background: Polycystic Ovary Syndrome (PCOS) increases the risk of cardiovascular diseases and diabetes, and obesity can acceler- ate this trend. Objectives: This study aimed at determining the effect of prebiotics on anthropometric indices in patients with this syndrome. Methods: This controlled clinical trial was conducted with 62 women from 18- to 45-year-old in the city of Tabriz, Iran, during years 2016 to 2017. Participants were assigned to prebiotic and control groups, using the random blocks method. The intervention group had a daily intake of 20 g of resistant Dextrin, dissolved in a glass of water for three months, and the placebo group had a daily intake of 20 g of Maltodextrin, dissolved in a glass of water for three months. Participants’ Body Mass Index (BMI), weight, waist circumference, and hip circumference were measured before, and three and six months after the intervention. Results: There was no significant difference between the groups in terms of baseline values (P > 0.05). Three months after the intervention, mean (SD) waist circumference, hip circumference, weight, and BMI was 78.11 (9.7), 100.85 (7.7), 65.31 (10.9), and 24.41 (4.2) in the prebiotic group and 86.54 (12.3), 108.72 (10.7), 73.25 (14.7), and 27.73 (5.7) in the control group, respectively. Six months afterthe intervention, mean (SD) anthropometric indices was 78.11 (7.9), 101.45 (7.2), 65.70 (10.3), and 24.54 (3.9) in the prebiotic group and 86.4 (12.6), 108.54 (10.8), 73.8 (14.7), and 27.65 (5.5) in the control group, respectively. According to the Analysis of Variance (ANOVA) test, and with controlled baseline values, all anthropometric indices were significantly lower in the prebiotic group compared to the control group at three (P < 0.001) and six months (P < 0.001).Conclusions: This study confirmed the positive and significant effects of prebiotics in reducing anthropometric indices, three and six months after the intervention in women with PCOS.
Hossein Ranjbaran; Saeid Abediankenari; Marzei Momeninezhad Amiri
Volume 20, Issue 3 , 2018, Pages 1-7
Abstract
Background: With regards to the high potential of medicinal plants in the production of biopharmaceuticals, one can rely on the promising prospect of insulin production via plant resources. Objectives: This study was conducted with the aim of using plant extract for insulin-producing cells. Methods: ...
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Background: With regards to the high potential of medicinal plants in the production of biopharmaceuticals, one can rely on the promising prospect of insulin production via plant resources. Objectives: This study was conducted with the aim of using plant extract for insulin-producing cells. Methods: This was a quasi-experimental study. In this study, critical case sampling was used. Six samples were gathered from the umbilical cord (Wharton’s jelly) at Imam hospital, after successful isolation of mesenchymal stem cells. Initially, Nigella sativa seeds extraction was performed to prepare the extract for cellular differentiation. Next, dithizone (DTZ) staining was used to evaluate insulin production and insulin level was examined by the enzyme linked immunosorbent assay (ELISA) kit. All data was analyzed with the SPSS version 16 software using independent sample t-test. Results: The mean of the amount of insulin secretion was 92.33 ± 5.13 for the intervention and 0.33 ± 0.15 for the control group. The results showed that there was a significant difference in the average insulin in the culture obtained from Nigella sativa seeds between control and intervention groups (P = 0.001). In addition, via the ELISA kit and specific dithizone staining, insulin-producing cells were proven. Conclusions: In this regard, it could be concluded that the extract of Nigella sativa seeds was capable in the induction of differenti- ation of mesenchymal stem cells derived from Wharton’s jelly to IPCs.
Havin Zandinava; Fahimeh Sehhatti Shafaei; Sakineh Mohammad-Alizadeh Charandabi; Ghanbari Homayi; Mojgan Mirghafourvand
Volume 19, Issue 4 , April 2017, , Pages 1-9
Abstract
Background: Gestational diabetes is a particular disorder during pregnancy which can cause complications for mother and fetus. One reason for the limited success in the treatment of diabetes is the lack of patient participation in the process of treatment. Selfcare education is an important principle ...
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Background: Gestational diabetes is a particular disorder during pregnancy which can cause complications for mother and fetus. One reason for the limited success in the treatment of diabetes is the lack of patient participation in the process of treatment. Selfcare education is an important principle in the treatment of diabetes that can enhance the quality of life.Objectives: This study aimed to determine the effect of educational package on self-care behavior, quality of life, FBS (Fasting Blood Sugar), and GTT (Glucose Tolerance Test) among women with gestational diabetes.Methods: This randomized controlled clinical trial was performed on 92 pregnant women with gestational diabetes (n = 46 in each group) referring to diabetes clinic of Tohid hospital in Sanandaj, Iran. The educational program was designed in four sessions (one session per week) for the intervention group and included routine prenatal care along with education on self-care through lecture and question and answer. The participants also received educational booklet at the end of the first session. The control group received only routine prenatal care. Before and four weeks after the intervention, self-care and quality of life questionnaires were completed by the participants in both groups, and fasting blood glucose and GTT were measured.Results: After adjusting for the baseline score, the mean score of self-care behaviors was significantly higher in the intervention group than the control group four weeks after the intervention [adjusted mean difference: 19.5; 95% confidence interval: 14.4 to 24.6; P < 0.001]. Also, by adjusting for the baseline values, there was a statistically significant difference in the mean level of blood glucose at the time points of one hour after GTT [-21.6; -32.1 TO -11.1; P < 0.001] and two hours after GTT [-17.3; -23.0 to -11.6; P < 0.001]. No statistically significant difference was seen in the FBS (P = 0.443) and quality of life (P = 0.264) four weeks after the intervention.Conclusions: Self-care education can improve self-care behavior in women with gestational diabetes and it is also effective in impaired glucose tolerance.
Hamid Najafipour; Mohammad Sadeghigoghari; Zeinab Kordestani; Ahmad Naghibzadeh Tahami; Marjan Ghavipisheh
Volume 19, Issue 4 , April 2017, , Pages 1-7
Abstract
Background: Musculoskeletal pain syndromes (MSPSs) are of the most common disorders in modern societies. Lack of early diagnosis and treatment of this syndrome may lead to significant disabilities later in life.Objectives: Due to shortage of information regarding the prevalence and related factors of ...
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Background: Musculoskeletal pain syndromes (MSPSs) are of the most common disorders in modern societies. Lack of early diagnosis and treatment of this syndrome may lead to significant disabilities later in life.Objectives: Due to shortage of information regarding the prevalence and related factors of MSPS in the south-east of Iran, this study aimed at determining MSPS and its relation to demographic variables and underlying diseases such as diabetes and hypertension in this area.Methods: This across sectional population-based study was conducted on 1700 individuals (15 - 80 years), who participated in the second phase of Kerman coronary artery disease risk factor study (KERCADRs), in Kerman, Iran, in 2016. A questionnaire containing demographic information, opium use, smoking and MSPS was completed. Blood pressure, fasting blood glucose and lipid levels were also measured.Results: From a total of 1700 participants, 41.6% weremales and 58.4% were females. Themean age of the participants was 47.8 years. The overall prevalence of MSPS was 65.5% that was more prevalent in women and increased with advancing age approaching the highest prevalence in the group above 75 years (78.4%) (adjusted odds ratio, AOR > 1.6). The prevalence increased with diabetes (AOR 1.5), overweight and obesity (OR 1.6, 2.2), and depression and anxiety (AOR 1.5, 2.3). In multivariate analysis, MSPS had no relationship with smoking, opium consumption, hypertension, level of education and dyslipidemia.Conclusions: Overall, more than 65% of the population over 15 years in Kerman suffer from MSPSs. If the rate of such complications is not reduced, this can exert heavy health-care costs on the Iranian health system given the existing trend of increase in the age and age-related diseases in the population.
Somayeh Mohammadi; Mehrangiz Ebrahimi-Mameghani; Seyed Rafie Arefhosseini; Parviz Fallah; Mohammad Asghari Jafarabadi; Sepideh Zununi; Masoud Soleimani; Mehdi Banitalebi Dehkordi; Hossein Ghanbarian
Volume 19, Issue 1 , January 2017, , Pages 1-10
Abstract
Background: MicroRNAs have recently been introduced as epigenetic regulators of glucose and lipid metabolic pathways, which are impaired in obesity and diabetes.Objectives: We evaluated the effects of calorie-restricted diet therapy on the circulating levels of miR-33b and miR-29a in relationship to ...
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Background: MicroRNAs have recently been introduced as epigenetic regulators of glucose and lipid metabolic pathways, which are impaired in obesity and diabetes.Objectives: We evaluated the effects of calorie-restricted diet therapy on the circulating levels of miR-33b and miR-29a in relationship to glucose and lipid metabolic parameters in obese patients with type 2 diabetes mellitus (T2DM).Methods: This randomized clinical controlled trial was performed on 30 eligible obese women with T2DM, randomly divided into two groups (control group, n = 15; diet therapy group, n = 15) for 10 weeks. Ten healthy women with normal weight were enrolled at the baseline of the study as controls. Demographic information, dietary intake, and anthropometric and biochemical indices were obtained before and after the study. Circulating miR-33b and miR-29a were assessed for all subjects using quantitative RT-PCR, and the fold change of each circulating miRNA was compared between groups.Results: The circulating levels of miR-29a and miR-33b in the diabetic women were higher (0.40-fold) and lower (1.43-fold), respectively, than normal levels. Diet therapy significantly increased the circulating level of miR-33b (P = 0.023, 0.97-fold upregulation) to normal levels. This increase was independently correlated with caloric restriction (95%CI: -0.004 to -0.0001, P = 0.022) and 2hPPBS (95%CI: -0.009 to -0.001, P = 0.035). No remarkable change was observed in circulating levels of miR-29a.Conclusions: Our findings introduced a novel therapeutic effect of diet therapy on circulating miRNAs in obese patients with T2DM. MiR-33b is an important therapeutic target in the treatment and prevention of T2DM and its complications.
