Barberry Administration and Pro-Oxidant–Antioxidant Balance in Patients With Metabolic Syndrome

AUTHORS

akram mohammadi 1 , Amirhossein Sahebkar 2 , 3 , Tayyebeh Kermani 1 , Marzieh Zhilaee 1 , Shima Tavallaie 1 , Majid Ghayour Mobarhan 4 , *

1 Biochemistry of Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Neurogenic Inflammation Research center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Biotechnology Research center, Mashhad University of Medical Sciences, Mashhad, Iran

4 Cardiovascular Research center, Mashhad University of Medical Sciences, Mashhad, Iran

How to Cite: mohammadi A, Sahebkar A, Kermani T, Zhilaee M, Tavallaie S, et al. Barberry Administration and Pro-Oxidant–Antioxidant Balance in Patients With Metabolic Syndrome, Iran Red Crescent Med J. 2014 ; 16(12):e95999. doi: 10.5812/ircmj.16786.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 16 (12); e95999
Published Online: December 14, 2014
Article Type: Research Article
Received: July 03, 2019
Accepted: April 20, 2014
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Abstract

Background: Metabolic syndrome is the constellation of several cardiometabolic risk factors, and is associated with a heightened risk of coronary heart disease (CHD). The pro-oxidant–antioxidant balance (PAB) is a measure of factors that promote and control oxidative stress. PAB may also be associated with the risk factors of CHD.

Objectives: This study aimed to explore the impact of supplementation with barberry, a fruit rich in antioxidants, on PAB in patients with metabolic syndrome.

Patients and Methods: A total of 106 patients diagnosed with metabolic syndrome were randomized in two groups: case and control. The case group received three capsules of barberry and the control group received three capsules of placebo for 6 weeks. Serum PAB was measured in all patients before and after the intervention.

Results: There was no significant difference between the groups regarding their baseline PAB values (P = 0.32). A significant decrease in PAB was observed in the barberry group (P = 0.022), whilst there was no significant change in the control group (P = 0.18). The magnitude of change in PAB during the study was significantly greater in the case group compared to the control group (P = 0.01).

Conclusions: Barberry supplementation reduces oxidative burden in patients with metabolic syndrome.

Keywords

Metabolic Cardiovascular Syndrome Berberidaceae Randomized Controlled Trial

© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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