Appropriate Anesthesia Regimen to Control Sevoflurane-Induced Emergence Agitation in Children; Propofol–Lidocaine and Thiopental Sodium–Lidocaine: A Randomized Controlled Trial

AUTHORS

Poupak Rahimzadeh 1 , Seyed Hamid Reza Faiz 1 , * , Mahmoudreza Alebouyeh 1 , Azadeh Dasian 1 , Azadeh Sayarifard 2

1 Department of Anesthesiology and Pain Medicine, Rasoul-Akram Medical Center, Iran University of Medical Sciences, Tehran, IR Iran

2 Preventive and Community Medicine specialist, Community Based Participatory Research Center, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, IR Iran

How to Cite: Rahimzadeh P, Faiz S H R, Alebouyeh M, Dasian A, Sayarifard A. Appropriate Anesthesia Regimen to Control Sevoflurane-Induced Emergence Agitation in Children; Propofol–Lidocaine and Thiopental Sodium–Lidocaine: A Randomized Controlled Trial, Iran Red Crescent Med J. 2014 ; 16(7):e95993. doi: 10.5812/ircmj.16388.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 16 (7); e95993
Published Online: July 05, 2014
Article Type: Research Article
Received: July 03, 2019
Accepted: January 28, 2014
Crossmark

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Emergence Agitation (EA) is a common problem in pediatric anesthesia. The current study evaluated the effect of intravenous lidocaine combined with propofol or thiopental sodium to control EA by sevoflurane in children.

Objectives: The current study aimed to compare the effectiveness of two anesthesia regimen propofol–lidocaine and thiopental sodium lidocaine to control sevoflurane-induced emergence agitation in children.

Patients and Methods: The study enrolled 120 children aged 12 to 36 months with retinoblastoma who underwent induction of anesthesia with sevoflurane for Eye Examination Under Anesthesia (EUA). Sampling was done at Rasoul-Akram Hospital in Tehran, Iran. The subjects were randomly assigned into four groups including: group one (thiopental sodium-lidocaine [TL]), group two (thiopental sodium-saline [TS]), group three (propofol-lidocaine [PL]), and group four (propofol-saline [PS]). Emergence agitation was assessed by using a five-point scoring scale, every 10 minutes during the first 30 minutes after admission to the recovery room.

Results: EA occurred in 24 cases (20%) of children. Incidence of EA in the TS, TL, PS, and PL groups were 21 (70%), 2 (6.7%), 1 (3.3%), and 0 (0%), respectively (P < 0.001). Nausea and vomiting after anesthesia did not occur in any of the patients. After removal of the endotracheal tube, laryngospasm complication occurrence in the TS group (10 cases) was higher than the other groups and no statistically significant difference was observed (P = 0.1).

Conclusions: Propofol–lidocaine anesthesia regimen was more effective to control the pediatric emergence agitation than the other combinations.

Keywords

Lidocaine Propofol Sevoflurane Thiopental Sodium Emergence Agitation

© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

This part is available in the PDF file.

References

  • 1.

    The references are available in the PDF file.

  • COMMENTS

    LEAVE A COMMENT HERE: