The Wound Healing Effects of Iloprost in Patients with Buerger’s Disease: Claudication and Prevention of Major Amputations

AUTHORS

A Afsharfard 1 , * , M Mozaffar 2 , F Malekpour 2 , A Beigiboroojeni 3 , M Rezaee 2

1 Professor of General and Vascular Surgery, Shohada Medical Center, Shaheed Beheshti University of Medical Sciences (SBMU), Tajrish Sq., Tehran, Tehran, Iran

2 Department of General and Vascular Surgery, Shohada Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran, Tehran, Iran

3 Isfahan University of Medical Sciences, Isfahan, Iran

How to Cite: Afsharfard A, Mozaffar M, Malekpour F, Beigiboroojeni A, Rezaee M. The Wound Healing Effects of Iloprost in Patients with Buerger’s Disease: Claudication and Prevention of Major Amputations, Iran Red Crescent Med J. 2011 ; 13(6):e95919.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 13 (6); e95919
Published Online: June 30, 2011
Article Type: Research Article
Received: July 02, 2019
Accepted: June 30, 2011

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: This study analyzes the therapeutic effects of intravenous infusion of iloprost in wound healing, healing of the amputation stump wound, improvement in intermittent claudication and prevention of major amputation in patients with Buerger’s disease.

Methods: In a prospective study, 19 patients with known Buerger’s disease, received intravenous iloprost infusion, 6 hours per day for 10 days. Iloprost with a dose of 0.5-2 ng/kg/min according to the patients’ tolerance and using cardiac monitoring during the whole infusion period was administered for 6 hours/day using saline solution. Patients with larger wounds underwent simultaneous transmetatarsal or Ray amputation of the involved toe(s). All patients were discharged after 10 days. Patients were followed to detect their healing changes.

Results: Nineteen patients, 19-55 years old received 0.5-2 ng/kg/min iloprost intravenously for 6 hours/day for 10 days. During this period, there was relative improvement in resting pain, but no significant amelioration was noticed in wound healing. In a 2 years follow-up, 14 patients showed a complete healing of the amputation stump and increased distance of walking without any pain. Some previous candidates of major amputation did not need amputation anymore. Five patients (26%) did not respond to therapy.

Conclusion: Although Buerger’s disease patients who were under iloprost therapy, may not show significant changes in wound healing during treatment and at discharge, late results have proved that iloprost infusion is promising in improving wound healing and claudication and preventing major amputations.

Keywords

Wound Healing Buerger’s disease Thromboangiitis oblitrans Iloprost

© 2011, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

This part is available in the PDF file.

References

  • 1.

    The references are available in the PDF file.

  • COMMENTS

    LEAVE A COMMENT HERE: