The Association between Sporadic Alzheimer’s Disease and the Human ABCA1 and APOE Gene Polymorphisms in Iranian Population

AUTHORS

Hamid Reza Khorram Khorshid 1 , * , E Gozalpour 1 , K Kamali 2 , M Ohadi 1 , M Karimloo 3 , MH Shahhosseiny 4

1 Genetic Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Tehran, Iran

2 Reproductive Biotechnology Research Centre, Avicenna Research Institute (ACECR), Tehran, Tehran, Iran

3 Epidemiology and Biostatistics Department, University of Social Welfare and Rehabilitation Sciences, Tehran, Tehran, Iran

4 Microbiology Department, Islamic Azad University, Shahr-e-Qods Branch, Tehran, Tehran, Iran

How to Cite: Khorram Khorshid H R, Gozalpour E, Kamali K, Ohadi M, Karimloo M, et al. The Association between Sporadic Alzheimer’s Disease and the Human ABCA1 and APOE Gene Polymorphisms in Iranian Population, Iran Red Crescent Med J. 2011 ; 13(4):e95918.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 13 (4); e95918
Published Online: April 30, 2011
Article Type: Research Article
Received: July 02, 2019
Accepted: April 30, 2011

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Abstract

Background: Apolipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimer’s disease (AD), is the main cholesterol carrier in the brain. ATP-binding cassette transporter A1 (ABCA1) gene on chromosome 9, which has been known by genome-wide AD linkage study, has an important role in cellular cholesterol efflux. This study determines the association between sporadic AD and the human ABCA1 and APOE gene polymorphisms in Iranian population.

Methods: 154 AD cases and 162 control subjects from Iranian population were genotyped for APOE genotypes and ABCA1 polymorphism (R219K).

Results: The frequency of ε2ε3 genotype was higher in control subjects comparing AD patients but was not significant (13% versus 5.8%) and ε3ε4 genotype frequency was significantly higher in AD cases comparing with control subjects. APOE-ε2 allele frequency in cases was lower than control subjects but this difference was not significant (4.5% versus 8%). Individuals carrying ε4 allele, developed AD 6.5 times more than non-carriers (OR=6.52, 95%CI=2.63-16.17). There was no significant association between ABCA1 polymorphism and AD.

Conclusion: Unlike other studies, R219K polymorphism was not dependent on gender and APOE-ε4 allele and there was no association between APOE and ABCA1 in AD patients compared to controls.

Keywords

Alzheimer’s disease Genetic association Apolipoprotein E Polymorphism ATP-binding cassette transporter A1 Iran

© 2011, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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