Intrafamily Transmission of HCV Need to More Discussion


Hong-Zhou Lu 1 , *

1 Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Caolang Road 2901#, Jinshan District, Shanghai,201508, PR China

How to Cite: Lu H. Intrafamily Transmission of HCV Need to More Discussion, Iran Red Crescent Med J. 2011 ; 13(2):e95914.


Iranian Red Crescent Medical Journal: 13 (2); e95914
Published Online: February 28, 2011
Article Type: Letter
Received: July 02, 2019
Accepted: February 28, 2011




Dear editor,

Chronic hepatitis C virus (HCV) infection is the major cause of liver disease related to high morbidity and mortality in hemophilic patients who needs regular blood product administration.1 Although genotype of infecting HCV is one of the prime predictors of response to antiviral therapy,2 however, its distribution in hemophilic patients is still unclear.3  

The article titled; Distribution of hepatitis C virus genotypes in Iranian patients with congenital bleeding disorders, revealed the genotype distribution of HCV in Iranian hemophilic patients.4 In this study, results demonstrate genotype 1a was the most frequent HCV genotype (58%), followed by genotype 3a (18.5%) and genotype 1b (14.7%). Mixed genotypes were also detected in 6.2%. These findings were compatible with other similar studies on HCV infected patients in Iran. In USA and Western Europe, HCV genotypes 1a and 3 are more predominant, 1b and 2 in South Europe and genotype 4 in Africa and Middle East.5 This pattern of HCV genotypes in Iranian hemophilic patients is similar to which of Western Europe and different to which of neighbor countries.

This work has enriched the data of genotype distribution in different areas. Nevertheless, genotype is an important parameter used in selecting an antiviral therapy and genotyping and subtyping of HCV is relevant to the epidemiology of HCV, I believe this article may give some suggestive help in clinical management against chronic HCV infection.


Intrafamily transmission HCV Hemophilia Iran

© 2011, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.


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