Survival of Male Breast Cancer in Fars, South of Iran

AUTHORS

A Salehi 1 , H Zeraati 1 , K Mohammad 1 , M Mahmoudi 1 , AR Talei 2 , A Ghaderi 3 , MH Imanieh 4 , A Fotouhi 5 , *

1 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Tehran, Iran

2 Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

3 Department of Immunology, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

4 Gastroenterohepatology Research Center, Department of Pediatric Gastroenterology, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

5 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, PO Box: 14155-6446, Tehran, Tehran, Iran

How to Cite: Salehi A, Zeraati H, Mohammad K, Mahmoudi M, Talei A, et al. Survival of Male Breast Cancer in Fars, South of Iran, Iran Red Crescent Med J. 2011 ; 13(2):e95905.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 13 (2); e95905
Published Online: February 28, 2011
Article Type: Research Article
Received: July 02, 2019
Accepted: February 28, 2011

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Abstract

Background: Although breast cancer in men is uncommonits incidence rate has an increasing trend. Due to its low incidence, there are few studies in this subject and limited information is available. The purpose of this study was to investigate clinicopathological characteristics and survival of male breast cancer (MBC) in Fars Province, south of Iran.

Methods: The data for this study were obtained from the population based cancer registry of Vice-Chancellor for Health Affairs of Shiraz University of Medical Sciences and Shiraz hospitals between January 1, 1989 and January 1, 2008, including 64 patients with MBC. Demographic, clinical and pathological aspects were investigated. The Kaplan-Meier method was used for the determination of survival rate and Log Rank test for the comparison. The Cox proportional hazards model was used for the multiple analysis.

Results: The patients’ mean age at the time of diagnosis was 60.3 years (SD=12.7). The most frequent age group (26.6%) was 51-60 years. The most common symptom (96.8%) was a palpable mass. The majority of patients (44.4%) had a symptom duration of less than or equal to 6 months. 56.3% of the patients had a tumor size of 2-4.9  cm. Forty six percent of the cases had axillary lymph node involvement. The median survival time was 10.0 years [95% confidence interval (CI): 6.0-14.0]. The 5 year overall survival rate was 66.0% (95% CI=51.0-81.0%). The median survival time of patients with axillary lymph node involvement was 8.2 years (95% CI=6.7-9.6) and for the cases without involvement was 12.0 years (95% CI=8.4-15.2). In addition to axillary lymph node involvement, positive family history in contrast to negative family history and left tumors in comparison with right tumors were poorer prognostic factors in univariate analysis respectively (p=0.006, p=0.031). In multiple analysis, axillary lymph node involvement was an independent predictor of poorer survival (Hazard ratio=1.6, 95% CI=1.1-6.4, p=0.030) and the other variables did not have a significant effect.

Conclusion: The mean age of MBC in this series is lower than that in western countries. It is compatible to the mean age of female breast cancer which is approximately one decade less than that in developed countries. The survival rate of MBC is relatively lower than that in western countries. Axillary lymph node involvement is an important prognostic factor in the survival of MBC. Multicenter population based studies with greater number of patients are required for better estimation of different aspects of MBC in Iran.

Keywords

Breast cancer Male Survival Iran

© 2011, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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