The Effect of BioGlue® on Cerebral Cortex in Experimen-tal Rats

AUTHORS

SM Rakei 1 , Abodolkarim Rahmanian 2 , * , A Safarian 3 , N Azarpira 4 , D Mehrabani 5

1 Department of Neurosurgery, Shiraz University of Medical Sciences, , Shiraz, Fars, Iran

2 Assistant Professor of Department of Neurosurgery, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

3 Department of Neurosurgery, Bushehr University of Medical Sciences, Bushehr, Iran

4 Transplant Research Center,Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

5 Stem Cell and Transgenic Technology Research Center, and Gastroenterohepatology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

How to Cite: Rakei S, Rahmanian A, Safarian A, Azarpira N, Mehrabani D. The Effect of BioGlue® on Cerebral Cortex in Experimen-tal Rats, Iran Red Crescent Med J. 2009 ; 11(1):e95873.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 11 (1); e95873
Published Online: January 31, 2009
Article Type: Research Article
Received: July 01, 2019
Accepted: January 31, 2009

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Abstract

Background: BioGlue® is a newly introduced sealant applied by several cardiovascular surgeons to seal graft anastomoses. This study was carried out to determine the effect of a synthetic BioGlue® on the repair of meninges in comparison with contemporary bioadhesives.

 

Methods: A synthetic BioGlue® was provided by combining 45% human serum albumin and 10% glutaraldehyde. Forty Wistar female rats were randomly divided into 4 equal groups (Two case and two control groups). After craniotomy, dural incision was performed and the motor cortex was exposed. In the case group, the motor cortex was exposed to BioGlue® and in the control group, the incision was closed without application of BioGlue®. The rats were studied histpathologically after 5 and 14 days postcraniotomy.

 

Results: Synthetic BioGlue® caused an acute inflammatory response that resulted in a delayed gliosis in the superficial cerebral cortex, but the deep layers and adjacent areas of cortex were spared. Inflammatory changes and gliosis did not cause cell apoptosis or necrosis. Histopathological changes did not have any clinical significance as they were not accompanied by any neurological deficit or motor weaknesses and exposure to synthetic BioGlue® could not cause any clinically significant neurological deficit either.

 

Conclusion: The simplicity of producing this new synthetic BioGlue® and its relative low cost, compared to other similar glues, opens a new horizon to the use of this synthetic BioGlue® in the neurosurgical field.

Keywords

Cerebral cortex Synthetic BioGlue® Pathology Rat

© 2009, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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