Serum Level of Matrix Metalloproteinase-3 in Patients with Oral Lichen Planus


M Farzin 1 , M Mardani 1 , J Ghabanchi 1 , MJ Fattahi 1 , M Rezaee 2 , ST Heydari 1 , A Andisheh Tadbir 3 , *

1 Department of Prosthodontics, Dental School, Shiraz University of Medical Sciences, Iran

2 Shiraz, Iran

3 Department of Oral Pathology, Dental School, Shiraz University of Medical Sciences, [email protected], Iran

How to Cite: Farzin M, Mardani M, Ghabanchi J, Fattahi M, M, et al. Serum Level of Matrix Metalloproteinase-3 in Patients with Oral Lichen Planus, Iran Red Crescent Med J. Online ahead of Print ; 14(1):10-13.


Iranian Red Crescent Medical Journal: 14 (1); 10-13
Article Type: Research Article
Received: May 5, 2011
Accepted: October 10, 2011




Background: Oral Lichen planus (OLP) is a chronic lesion of the oral mucosa with unknown origin. Basement membrane changes are common in OLP and may be mediated by proteases such as matrix metalloproteinase (MMPs) and mast cell chymase. The aim of our study was to evaluate the level of serum MMP-3 in OLP compared to normal individuals and assess its clinical significance.


Methods: Thirty fourserum samples from patients diagnosed with OLP (12 males, 22 females, age: 42.2±10.8 years) and 34 serum samples from healthy control subjects (11 males, 23 females, age: 42.5±13.3  years) were collected and MMP-3 concentration  was measured by ELISA.


Results: The serum MMP-3 level in OLP patients was higher (21.64±24.31 ng/ml) compared with healthy controls (16.52±23.63 ng/ml), but showed no statistically significant difference. A statistically significant difference was demonstrated between the two types of OLP, being more pronounced in the erosive/atrophic form 6).


Conclusion: The different clinical appearances of OLP are associated with significant differences in MMP-3 serum level.


Oral Lichen planus Matrix metalloproteinase-3

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