HSV-2 Seroepidemiology and Risk Factors among Iranian Women: A Time to New Thinking


S Asgari 1 , L Chamani-Tabriz 2 , * , S Asadi 3 , F Fatemi 3 , H Zeraati 3 , MM Akhondi 3 , A Shahnazi 4

1 International Campus, Tehran University of Medical Sciences, Iran

2 Assistant Professor of Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, [email protected], Iran

3 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Iran

4 International Campus, Tehran University of Medical Sciences, Iran

How to Cite: Asgari S, Chamani-Tabriz L, Asadi S, Fatemi F, Zeraati H, et al. HSV-2 Seroepidemiology and Risk Factors among Iranian Women: A Time to New Thinking, Iran Red Crescent Med J. Online ahead of Print ; 13(11):818-823.


Iranian Red Crescent Medical Journal: 13 (11); 818-823
Article Type: Research Article
Received: May 20, 2011
Accepted: August 21, 2011




Background: Genital herpes is a common sexually transmitted disease in many developed and developing countries mostly caused by Herpes simplex virus type 2 (HSV-2). This study determines the prevalence of HSV-2 infection between two groups of women with high and low risk behaviors.


Methods: In this seroepidemiologic study, 362 women attending obstetrics and gynecology clinics as low risk group and 156 prisoners and drop in center resident women in Tehran as high risk group were enrolled. HSV infection was identified by serologic tests on blood samples.


Results: The prevalence of IgG antibody in high risk group was significantly more than low risk women (26.3% vs. 2.5%). The prevalence of IgM antibody in high risk group was less than low risk group (3.8% vs. 7.1%) but the difference was not statistically significant. In high risk group, there was significant association between positive IgG and anal/oral sex, use of condom, smoking and drug addiction as well as genital pain, burning, itching, ulcer, dysuria, and history of genital infection. In low risk group, association between positive IgM and IgG test results and risky behaviors were not significant. There was significant association between IgM and genital itching, rash, and ulcer.


Conclusion: Relatively high seroprevalence of anti-HSV-2 IgG and high frequency of genital Herpes among high risk women necessitates regular screening and safe sex education programs. Moreover, risk of acute infection in this group should not be ignored and its distribution in Iranian population should be alarmingly concerned.


Genital Herpes Simplex Virus Female Behavior Iran

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