Effect of Pentoxifylline Administration on Mast Cell Numbers and Degranulation in a Diabetic and Normoglycemic rat Model Wound Healing

AUTHORS

Saeid Babaei 1 , Mohammad Bayat 2 , *

1 Cellular and Molecular Biology Research Center,Medical Faculty,Shahid Beheshti University, IR Iran

2 Cellular and Molecular Biology Research Center,Medical Faculty,Shahid Beheshti University, [email protected], IR Iran

How to Cite: Babaei S, Bayat M. Effect of Pentoxifylline Administration on Mast Cell Numbers and Degranulation in a Diabetic and Normoglycemic rat Model Wound Healing, Iran Red Crescent Med J. Online ahead of Print ; 14(8):483-487.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 14 (8); 483-487
Article Type: Research Article
Received: January 9, 2012
Accepted: July 14, 2012

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Wound healing is a complicated and integrated process. Researches in the molecular level on human and animal models have indicated several molecular changes related to the effect of diabetes on wound healing process.
Objectives:
Increasing number of researches implicates the influence of mast cells on skin wound repairing. In this study the effect of systemic pentoxifylline (PTX) administration (daily dose of 25mg/kg twice a day, for 7 consecutive days) on normoglycemic (NG) and diabetic (DB) wistar rat’s wound healing by secondary intention was studied.
Materials and Methods:
In this study forty eight wistar rats (weighting 250-350g) were divided randomly in two groups: Normoglycemic and diabetic,  each group was divided into experimental and control  groups,  experimental received  intraperitoneal (PTX) and controls received distilled water(DW). The number and maturing process of mast cells was evaluated by counting the number of types of mast cells (1, 2, 3) microscopically and by stereological methods on day 3 and 7 after surgery.
Results:
In this study it was cleared that in wound healing process  PTX caused  increasing  the number of type 2 mast cells in all experimental groups(P = 0.00). In normoglycemic experimental group, receiving PTX there was decrease in the number of type3 mast cells, comparing experimental NG groups (P = 0.00).
Conclusions:
In all PTX treated groups delay in converting type 2 into type 3 mast cell was seen. Pentoxifylline causes decreasing mast cell degranulation in wound healing process.


Please cite this paper as:
Babaei S, Bayat M. Effect of Pentoxifylline Administration on Mast Cell Numbers and Degranulation in a Diabetic and Normoglycemic rat Model Wound Healing. Iran Red Crescent Med J.2012;14(8):483-7.

Keywords

Pentoxifylline Mast cells Diabetes Mellitus Wound Healing

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: