Efficacy of Influenza Vaccination in Patients with Cirrhosis and Inactive Carriers of Hepatitis B Virus Infection

AUTHORS

B Sayyad 1 , SM Alavian 2 , * , F Najafi 3 , T Mokhtari Azad 4 , MH Ari Tabarestani 1 , M Shirvani 1 , B Behnava 2 , M Afshrian 1 , S Vaziri 1 , AR Janbakhsh 1 , F Mansouri 1

1 Kermanshah Liver Diseases and Hepatitis Research Center, Kermanshah University of medical Sciences, Iran

2 Baqyatallah Research Center for Gastroenterology and Liver Disease, [email protected], Iran

3 Kermanshah Health Research Center, Kermanshah University of medical Sciences, Iran

4 Department of Virology, School of Public Health, Tehran University of Medical Sciences, Iran

How to Cite: Sayyad B, Alavian S, Najafi F, Mokhtari Azad T, Ari Tabarestani M, et al. Efficacy of Influenza Vaccination in Patients with Cirrhosis and Inactive Carriers of Hepatitis B Virus Infection, Iran Red Crescent Med J. Online ahead of Print ; 14(10):623-630.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 14 (10); 623-630
Published Online: October 30, 2012
Article Type: Research Article
Received: July 23, 2011
Accepted: February 20, 2012

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Abstract

Background: Influenza can causes morbidity and mortality that are greatly enhanced in patients with underlying chronic diseases such as Cirrhotic patients. This study was performed to assess the immunogenicity of Influenza vaccination in patients with cirrhosis and inactive carriers of Hepatitis B virus infection.

Methods: In this clinical study 93 enrolled subjects divided into 3 groups: Cirrhotic (N=28), Inactive carriers of Hepatitis B (N=31) and subjects (N=34). All the participants were vaccinated by Influenza vaccine (Influvac). Serum samples were taken before and 4 weeks after vaccination and the Humoral Immunogenicity was assessed by the Hemagglutination iInhibition (HI) test.

Results: Four weeks after vaccination, seroconversion rates of vaccine strains ranged between 71.4% and 100% in Group 1, 70.6% and 94.1% in Group 2, and 58.1% and 80.7% in Group 3. No significant differences were seen in the rates of Seroconversion and antibody Geometric Mean Titers (GMTs) against Influenza A (H1N1 and H3N2) vaccine components in the three groups (P>0.05).The rates of Seroconversion and antibody GMTs against Influenza B vaccine component were significantly higher in Cirrhotic and inactive carriers of Hepatitis B than healthy subjects (P<0.005). No significant (P>0.05) differences in the rates of Seroprotection were observed within the three groups. Antibody GMTs against all three strains of Influenza vaccine increased significantly (P<0.001) after vaccination in three groups.

Conclusion: Influenza vaccination is effective in Cirrhotic patients and inactive carriers of Hepatitis B as well as healthy individuals. It means that vaccination should be considered in such patients in order to reduce the morbidity and mortality of Influenza.

Keywords

Influenza Vaccination Cirrhosis Hepatitis B

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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