Antinociceptive Effects of Melisa Officinalis Aerial Parts Extracts in Mice

AUTHORS

H Hosseinzadeh 1 , * , M Ramezani 2 , A Haghgoo 2

1 Department of Pharmacology, Mashhad -University of Medical Sciences, [email protected], Khorasan-Razani, Iran

2 Department of Pharmacology, Mashhad -University of Medical Sciences, Khorasan-Razani, Iran

How to Cite: Hosseinzadeh H, Ramezani M, Haghgoo A. Antinociceptive Effects of Melisa Officinalis Aerial Parts Extracts in Mice, Iran Red Crescent Med J. Online ahead of Print ; 8(1):7-12.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 8 (1); 7-12
Article Type: Research Article

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: some labiate family plants show antinociceptive activities, Melisa officinalis belongs to this family, thus, antinociceptive activity of the aqueous decoction and ethanolic maceration extracts of the aerial parts of this plant studied in mice.
    Results: antinociceptive activities were done using hot-plate and writhing tests.in hot-plate and writhing tests, the intraperitonial injection of both extracts showed significant antinociceptive activity in mice. Naloxone, an opioid antagonist, pre-treatment, inhibited the antinociceptive activity of the extracts in hot-plate test. The extracts exhibited antinociceptive activity against acetic acid induced writhing which was partially blocked by naloxone.
    Conclusion: it is concluded that the aqueous decoction and elhanolic maceration of the aerial parts of M, officinal is has antinociceptive effects and this may be mediated partially by opioid receptors.

Keywords

Key words: antinociceptive, Melisa officinalis, effects

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: