Detection of Mycobacterial antigen and antibody in

AUTHORS

N Hadi 1 , * , M Kabiri 2

1 Instructor of Bacteriology and Virology Department,Medical School,Shiraz University of Medical Sciences, [email protected], Fars, Iran

2 Shiraz, Iran

How to Cite: Hadi N, Kabiri M. Detection of Mycobacterial antigen and antibody in, Iran Red Crescent Med J. Online ahead of Print ; 9(2):74-79.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 9 (2); 74-79
Article Type: Research Article

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Abstract

Background: Little is known about changes in total antibodies occurring during the progression of tuberculosis or its treatment. Using passive and reverse passive hemagglutination methods, mycobacterial antibody and antigen were determined in sera of patients with acute smear-positive pulmonary tuberculosis.

 

Methods: Fifty-nine patients were studied in different groups according to the duration of treatment in various stages of disease. The first group that did not undergo treatment showed a very low level of antibody. The second group with less than 6 months of therapy had a mean antibody titer of about 1:70. The third group underwent therapy for more than 6 months and their mean antibody titer was about 1:970. The fourth group whose disease was under control and their treatments were discontinued, showed the highest level of antibodies (1:2760).

 

Results: A significant difference was found between the average antibody titers and the duration of treatment and course of disease. No antigen was detected in any patients except in group 5.

Conclusion: A high antibody response seemed to occur after treatment when the bacteria were disrupted and their antigens released. Absence of antigen may be due to the formation of antigen-antibody complexes. 

Keywords

Tuberculosis PPD Antituberculous antibody Reverse passive hemagglutination

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