Toxoplasmosis in HIV/AIDS patients in Shiraz,southern Iran


MA Davarpanah 1 , * , D Mehrabani 2 , R Neirami 3 , M Ghahremanpoori 3 , M Darvishi 3

1 Gastroenterohepatology Research Center,Nemazee Hospital,Shiraz University of Medical Sciences, [email protected], Fars, Iran

2 General Practitioner Shiraz University of Medical Sciences, fars, Iran

3 General Practitioner Army University of Medical Sciences, Tehran, Iran

How to Cite: Davarpanah M, Mehrabani D, Neirami R, Ghahremanpoori M, Darvishi M. Toxoplasmosis in HIV/AIDS patients in Shiraz,southern Iran , Iran Red Crescent Med J. Online ahead of Print ; 9(1):22-27.


Iranian Red Crescent Medical Journal: 9 (1); 22-27
Article Type: Research Article




Background: Toxoplasma gondii is an intracellular protozoan parasite, and causes zoonotic infection. Human latent toxoplasmosis occurs in about half the world's population though most cases are asymptomatic. Toxoplasma encephalitis (TE) has become one of the more frequent opportunistic infection in HIV infected patients.


Methods: This retrospective and descriptive study was carried out at the Referral Behavioral Counseling and Modification Center in Shiraz, Iran. We were able to review the medical records of 208 HIV infected patients. They were examined and their records were screened via the standardized data collection sheet for demographic characteristics. Diagnoses of TE based on the presence of at least two of the following findings: a history of neurological symptoms, neurological signs, suggestive CT, clinical and radiological response to antitoxoplasmosis medication.


Results: The seroprevalence of toxoplasmosis among 208 HIV/AIDS patients was (18.2%) (38 patients) while 4 (10.4%) and 34 (89.6%) subjects showed Toxoplasma seropositivity with and without TE respectively. The majority of these patients were in the 25-34 age group, male, unemployed, single and residence in Shiraz, southern Iran.


Conclusion: Toxoplasmosis is a silent disease, which poses many diagnostic and therapeutic challenges. Based on findings of this study, we support a screening program of Toxoplasma infection. Primary chemoprophylaxis should be routinely given to all HIV infected with Toxoplasma seropositive status. Also HIV infected individuals with Toxoplasma seronegative status may be advised about preventive behavioral practice. 


HIV Toxoplasmosis Toxoplasma encephalitis

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF