The Association between Y Chromosome Microdeletion and Recurrent Pregnancy Loss


S Ghorbian 1 , K Saliminejad 1 , MR Sadeghi 1 , GhR Javadi 1 , K Kamali 1 , N Amirjannati 1 , F Bahreini 1 , H Edalatkhah 1 , HR Khorram Khorshid 2 , *

1 Department of Biology, Science and Research Branch, Islamic Azad University, Iran

2 Reproductive Biotechnology Research Center, Avicenna Research Institute, Shahid Beheshti University, [email protected], Iran

How to Cite: Ghorbian S, Saliminejad K, Sadeghi M, Javadi G, Kamali K, et al. The Association between Y Chromosome Microdeletion and Recurrent Pregnancy Loss, Iran Red Crescent Med J. Online ahead of Print ; 14(6):358-362.


Iranian Red Crescent Medical Journal: 14 (6); 358-362
Article Type: Research Article
Received: November 27, 2011
Accepted: February 5, 2012




Background: To date, the role of male factor contributing in evaluation of spontaneous recurrent pregnancy loss (RPL) has been less investigated and there is discrepancy in the role of Y chromosome microdeltions in RPL. Therefore, the current study was designed to examine whether Y chromosome microdeletions were associated with RPL in an Iranian population.


Methods: One hundred men from couples, experiencing three or more RPLs, and one hundred normal men from couples with at least one child and no history of miscarriages as control group were included. Genomic DNA was extracted from peripheral blood and tested for Y chromosome microdeletions in AZFa, AZFb and AZFc regions using two multiplex PCR.


Results: None of the men in the case and control groups had any microdeletions in the AZFa, AZFb and AZFc regions.


Conclusion: It seems that Y chromosome microdeletion is not associated with recurrent pregnancy loss, therefore performing this test in Iranian couples with RPL is not recommended.


Infertility Recurrent pregnancy loss Miscarriages Y chromosome microdeletion AZF regions

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