The Relationship between Exposure to Pesticides and the Occurrence of Lymphoid Neoplasm


M Zakerinia 1 , * , M Namdari 2 , S Amirghofran 2

1 Associate Professor of Internal Medicine, The Director of Bone Marrow Transplant Unit, Department of Internal Medicine, Hematology Research Center, Shiraz University of Medical Sciences, [email protected], Iran

2 Department of Internal Medicine, Shiraz University of Medical Sciences, Iran

How to Cite: Zakerinia M, Namdari M, Amirghofran S. The Relationship between Exposure to Pesticides and the Occurrence of Lymphoid Neoplasm, Iran Red Crescent Med J. Online ahead of Print ; 14(6):337-344.


Iranian Red Crescent Medical Journal: 14 (6); 337-344
Article Type: Research Article
Received: January 10, 2012
Accepted: March 25, 2012




Background: The etiology of malignant lymphoma is still largely unknown. This study determines the relationship between exposure to pesticides and the occurrence of lymphoid neoplasms in Shiraz, Southern Iran.


Methods: Between 2007 and 2008, in a case control study conducted in Nemazee Hospital in Shiraz, Southern Iran, 200 subjects diagnosed with lymphoma according to the World Health Organization (WHO) classification were enrolled. Controls (n=200) were frequency matched to the cases by sex, age, and center. Subjects who were a farmer were compared with all other occupations.  


Results: Out of the 200 cases that were diagnosed as lymphoid neoplasms, 100 were non-Hodgkin's lymphoma, 54 Hodgkin's lymphoma and 46 multiple myeloma. Seventy two percent of the NHL's were of the B-cell type, 15% of the T-cell type and the rest were not classified. Furthermore, subjects exposed to pesticides were at an increased risk of non-Hodgkin lymphoma and MM, but not Hodgkin lymphoma.


Conclusion: Risk of non-Hodgkin lymphoma and MM was highest for exposure to pesticides, among them, insecticide's risk was confirmed.


Exposure Pesticide Non-Hodgkin lymphoma Hodgkin lymphoma Multiple myeloma

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