Serologic Detection of Anti Toxoplasma gondii Infection in Diabetic Patients

AUTHORS

Shahnaz Shirbazou 1 , * , Ali Delpisheh 2 , Rahim Mokhetari 1

1 Department of Parasitology, Baqiyatallah University of Medical Sciences, Tehran, IR Iran

2 Department of Clinical Epidemiology and Prevention of Psychosocial Injuries, Research Centre, Ilam University of Medical Sciences, Ilam, IR Iran

How to Cite: Shirbazou S, Delpisheh A, Mokhetari R. Serologic Detection of Anti Toxoplasma gondii Infection in Diabetic Patients, Iran Red Crescent Med J. Online ahead of Print ; 15(8):701-703. doi: 10.5812/ircmj.5303.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 15 (8); 701-703
Published Online: August 4, 2013
Article Type: Research Article
Received: May 13, 2012
Accepted: June 13, 2013
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Abstract

Background: Toxoplasmosis is caused by the Toxoplasma gondii parasite. The parasite is intracellular and can result in severe complications leading to death in immuno-deficient patients in particular. Diabetes is an important factor that increases susceptibility and risk of various infections in the host.

Objectives: The present study focused on the serologic detection of Toxoplasma gondii infection in diabetic patients.

Materials and Methods: Through a case-control study, overall 184 serum samples including 91 from diabetic cases and 93 from healthy non-diabetic controls were investigated. Cases and controls were matched for age and gender. Serum samples were tested for sugar by an enzymatic method, and IgG antibodies were tested against Toxoplasma gondii by ELISA method.

Results: The prevalence of IgG antibodies against Toxoplasma gondii in diabetic patients and healthy controls were 60.43% and 38% respectively. Risk of toxoplasmosis infection in diabetic patients with was two folds higher than healthy controls (RR = 2.31, 93% CI; 1.6 3.7, P = 0.001).

Conclusions: Diabetes may be caused by Toxoplasma gondii. Presence of T. gondii in the pancreas at the same time could directly undermines the pancreas cells. When ? cells are destroyed, insulin secretion would then be affected. Probably the destruction of T. gondii affects nervous system and damages pancreatic cells leading to increased risk of diabetes.

Keywords

Diabetes Infection Serum Toxoplasma gondii

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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