Seroepidemiology of HBV Infection in South-East of Iran; A Population Based Study


M Salehi 1 , SM Alavian 2 , * , SV Tabatabaei 3 , Sh Izadi 1 , E Sanei Moghaddam 1 , S Amini Kafi-abad 4 , A Gharehbaghian 4 , S Khosravi 4 , H Abolghasemi 4

1 Research Center for Infectious Disease and Tropical Medicine, Zahedan University of Medical Sciences, Iran

2 Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Ground floor of Baqiyatallah Hospital, Mollasadra Ave., Vanak Sq., P.O.Box 14155-3651, [email protected], Iran

3 Westflische Wilhelms-Universitt Mnster, St.-Marien-Hospital GmbH, Gastroenterologishe Klinik, Germany

4 Iranian Blood Transfusion Organization Research Center, Iran

How to Cite: Salehi M, Alavian S, Tabatabaei S, Izadi S, Sanei Moghaddam E, et al. Seroepidemiology of HBV Infection in South-East of Iran; A Population Based Study, Iran Red Crescent Med J. Online ahead of Print ; 14(5):283-288.


Iranian Red Crescent Medical Journal: 14 (5); 283-288
Article Type: Research Article
Received: October 28, 2011
Accepted: January 9, 2012




Background: Hepatitis B virus (HBV) infection is a major risk factor of cirrhosis and hepatocellular carcinoma affecting billions of people globally. Since information on its prevalence in general population is mandatory for formulating effective policies, this population based serological survey was conducted in Sistan and Baluchistan, where no previous epidemiological data were available.


Methods: Using random cluster sampling 3989 healthy subjects were selected from 9 districts of Sistan and Baluchistan Province in southeastern Iran. The subjects’ age ranged from 6 to 65 years old. Serum samples were tested for HBcAb, HBsAg. Screening tests were carried out by the third generation of ELISA. Various risk factors were recorded and multivariate analysis was performed.


Results: The prevalence of HBsAg and HBcAb in Sistan and Baluchistan was 3.38% (95% CI 2.85; 3.98) and 23.58% (95% CI 22.29; 24.93) respectively. We found 8 cases of positive anti-HDV antibody. Predictors of HBsAg or HBcAb in multivariate analysis were age, marital status and addiction.


Conclusion: The rate of HBV infection in Sistan and Baluchistan was higher than other parts of Iran. Approximately 25% of general population in this province had previous exposure to HBV and 3% were HBsAg carriers. Intrafamilial and addiction were major routes of HBV transmission in this province.


Epidemiology Hepatitis HBV Iran

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