Relationship between Low Birth Weight Neonate and Maternal Serum Zinc Concentration


N Khadem 1 , A Mohammadzadeh 2 , * , AS Farhat 1 , L Valaee 1 , M Khajedaluee 1 , SMR Parizadeh 1

1 Department of Obstetrics and Gynecology, Neonatal Research Center, Mashhad University of Medical Sciences, Iran

2 Professor of Neonatal Research Center, School of Medicine, Mashhad University of Medical Sciences, [email protected], Iran

How to Cite: Khadem N, Mohammadzadeh A, Farhat A, Valaee L, Khajedaluee M, et al. Relationship between Low Birth Weight Neonate and Maternal Serum Zinc Concentration, Iran Red Crescent Med J. Online ahead of Print ; 14(4):240-244.


Iranian Red Crescent Medical Journal: 14 (4); 240-244
Article Type: Brief Report
Received: November 6, 2011
Accepted: January 12, 2012




Background: Zinc deficiency can lead to clinically relevant disturbances in tissue functions and particularly important for birth weight of neonates. The aim of this study was to determine the relationship between serum zinc in pregnant women and the incidence of low birth weight (<2500 g) in their newborns. 


Methods: This case-control study was done on women who delivered low birth weight infants (Cases), and normal birth weight infants (Controls).  Blood samples got in all women within 5 minutes of delivery, and assessed the concentration of zinc using electro-thermal atomic absorption spectrometry.  Serum concentration of zinc was compared.


Results: One hundred and seventeen mothers were enrolled, of them, 65 cases were low birth weight infants (1845±472 g) and 52 were controls (3166± 435 g).  Mothers in the case and control groups did not differ in age, body mass index, and socioeconomic or demographic factors. Maternal zinc concentration differed between cases and controls; 753.34±15 μg/l vs. 654.76±12 μg/l respectively. Maternal zinc differed between premature and full term deliveries.


Conclusion: Maternal zinc concentration was shown to affect birth weight and prematurity.


Zinc Low birth weight Pregnant

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