The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model


S Ashkani-Esfahani 1 , MH Imanieh 1 , M Khoshneviszadeh 1 , A Meshksar 1 , A Noorafshan 2 , * , B Geramizadeh 1 , S Ebrahimi 1 , F Handjani 1 , N Tanideh 1

1 Student Research Committee, Shiraz University of Medical Sciences, Iran

2 Department of Anatomy, Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, [email protected], Iran

How to Cite: Ashkani-Esfahani S, Imanieh M, Khoshneviszadeh M, Meshksar A, Noorafshan A, et al. The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model, Iran Red Crescent Med J. Online ahead of Print ; 14(2):70-74.


Iranian Red Crescent Medical Journal: 14 (2); 70-74
Article Type: Research Article
Received: August 12, 2011
Accepted: November 14, 2011




Background: Finding more efficient agents with fewer side effects for treatment of burns has always been a concern for researchers. Silver sulfadiazine (SSD), apparently due to its antimicrobial effect, is still one of the most common prescribed agents. Previous studies suggested that Arnebia euchroma (AE) has shown antimicrobial and anti-inflammatory activities. This study investigates the healing effect of AE extract in comparison with SSD in second degree burn wounds.


Methods: Fort eight female Wistar rats (220±20 g) were divided into four groups. Standard second degree burn wounds were induced on the back of their necks. One group was treated with SSD; two groups were treated with AE cream at concentrations of 10% (AE10) and 20% (AE20) and the control group which received no treatment. The duration of treatment was 28 days.


Results: This study revealed that AE and SSD noticeably improved re-epithelization, fibroblasts proliferation, and collagen bundle synthesis and had a noticeable anti-inflammatory effect compared with the control group.


Conclusion: Results of the present study revealed that Arnebia euchroma herbal extract was an effective treatment for second degree burn wounds when compared with SSD.


Healing Arnebia euchroma Burn Wound Rat

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