The Effect of Calendula Officinalis in Therapy of Acetic Acid Induced Ulcerative Colitis in Dog as an Animal Model

AUTHORS

D Mehrabani 1 , M Ziaei 1 , SV Hosseini 1 , L Ghahramani 1 , AM Bananzadeh 1 , MJ Ashraf 1 , A Amini 1 , M Amini 1 , N Tanideh 2 , *

1 Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Iran

2 Assistant Professor of Stem Cell and Transgenic Technology Research Center, Department of Pharmacology, Shiraz University of Medical Sciences, [email protected], Iran

How to Cite: Mehrabani D, Ziaei M, Hosseini S, Ghahramani L, Bananzadeh A, et al. The Effect of Calendula Officinalis in Therapy of Acetic Acid Induced Ulcerative Colitis in Dog as an Animal Model, Iran Red Crescent Med J. Online ahead of Print ; 13(12):884-890.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 13 (12); 884-890
Article Type: Research Article
Received: June 10, 2011
Accepted: August 15, 2011

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Abstract

Background: In patients with ulcerative colitis (UC), the repeated cycle of injury and repair of intestinal mucosa has been reported to increase the risk of colon cancer. So, a safe and efficient therapy is required for the treatment and prophylaxis for the disease.This study aims to investigate the efficacy of Calendula officinalis extract in treatment of experimentally induced ulcerative colitis in dog animal model.

 

Methods: During fall 2010, 10 out-bred female German dogs (1-2 years old; weighs of 20-25 kg) were enrolled. Ulcerative colitis was induced with 6% acetic acid as enema and method of treatment was retrograde (via enema) too by C. officinalis.

 

Results: Loose stools, diarrhea, gross bleeding and loss of body weight happened after administration of acetic acid and crypt damage, loss of epithelium, infiltration of inflammatory cells and depletion of goblet cells were noticed histologically. C. officinalis could successfully resolve the damages of UC.

 

Conclusion: Treatment with C. officinalis can broaden the current therapy options for UC.

Keywords

Ulcerative colitis Acetic acid Calendula officinalis Therapy Dog

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