Effects of Acetaminophen consumption in asthmatic children

AUTHORS

S Oshnouei 1 , Sh Salarilak 2 , * , A Khalkhali 3 , M Karamyar 4 , Mh Rahimi Rad 5 , A Delpisheh 6

1 MSc student of Epidemiology, Epidemiology and Biostatistics Department, Faculty of Medicine, Iran

2 Associate Professor of Epidemiology, Public Health Department, Faculty of Medicine, Islamic Azad University, Tabriz Branch, [email protected], Iran

3 3Assistant Professor of Biostatistics, Epidemiology and Biostatistics Department, Faculty of Health, Iran

4 Associate Professor of Pediatrics, Pediatrics Department, Faculty of Medicine, Iran

5 Associate Professor of pulmonary Diseases, Faculty of Medicine, Iran

6 Associate Professor of Epidemiology, Public Health Department, Faculty of Health, Iran

How to Cite: Oshnouei S, Salarilak S, Khalkhali A, Karamyar M, Rahimi Rad M, et al. Effects of Acetaminophen consumption in asthmatic children , Iran Red Crescent Med J. Online ahead of Print ; 14(10):641-646.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 14 (10); 641-646
Published Online: October 30, 2012
Article Type: Research Article
Received: November 11, 2011
Accepted: June 22, 2012

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Abstract

Background: Acetaminophen exposure might be associated with increasing risk of asthma prevalence and other atopic disorders over recent decades. The present study aimed to investigate the association between acetaminophen exposure and the risk of developing childhood asthma.

Methods: A case - control study was undertaken between March and September 2010 in Urmia district north west of Iran. Subjects were children aged between 2 - 8 years old. Cases were asthmatic children diagnosed based on GINA criteria (n=207) and controls were children without asthma symptoms (n=414) using 1:2 sampling method. Cases and controls were matched for age and gender. Clinical data including Acetaminophen exposure was collected by a questionnaire which completed by interviewing with parents/ guardians.

Results: Using Acetaminophen during the first year of life had no any effect on the risk of asthma (p=0.19), but amongst 2-8 years old children, this association was observed (p<0.001). There was also a dose response association between Acetaminophen consumption and risk of asthma (OR: 3.8; 95% CI; 2.15 6.59 for once per 2 to 3 month and OR: 4.2; 2.50 - 7.3 for at least one per month).

Conclusions: Using Acetaminophen increases risk of asthma among 2 - 8 years old children. However stronger evidences are required to design evidence-based guidelines to reduce acetaminophen consumption following post - vaccination and other febrile disorders.

Keywords

Acetaminophen Childhood asthma

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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