Effect of Metformin on Serum Ferritin Level in Women with Polycystic Ovary Syndrome


S Behradmanesh 1 , GhH Ranjbar Omrani 2 , F Ghazanfarpour 3 , A Baradaran 4 , *

1 Department of Internal Medicine and Endocrinology, Shahr-e-Kord University of Medical Sciences, Iran

2 Department of Internal Medicine and Endocrinology, Endocrine and Metabolic Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, Iran

3 Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Iran

4 Associate Professor of Pathology, Al-Zahra Medical Center, Isfahan University of Medical Sciences, [email protected], Iran

How to Cite: Behradmanesh S, Ranjbar Omrani G, Ghazanfarpour F, Baradaran A. Effect of Metformin on Serum Ferritin Level in Women with Polycystic Ovary Syndrome, Iran Red Crescent Med J. Online ahead of Print ; 13(7):487-492.


Iranian Red Crescent Medical Journal: 13 (7); 487-492
Article Type: Research Article
Received: October 15, 2010
Accepted: February 12, 2011




Background: Polycystic ovary syndrome (PCOS) is one of the most common diseases among women associated with various inflammatory reactants such as C-reactive protein (CRP) and ferritin. This study aimed to investigate the effect of metformin on probable reduction of serum ferritin in patients with PCOS.

Methods: This study was conducted on 45 patients with PCOS who had not other systemic diseases and did not take any medications. Weight, waist and hip circumstances (WHR), body mass index (BMI), metabolic indexes, CRP, ferritin and “Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) ? were measured before the study. Metformin (500 mg/tid) tablets were prescribed for three months and then same above parameters were re-measured.

Results: Of 45 patients, 19 (42.2%) were overweight and 14 (31.1%) were obese. After drug therapy, there was a significant reduction in waist circumstance and serum ferritin. This reduction was significant only in the lean and overweight groups but not in the obese group. There was not significant association between serum ferritin and CRP, HOMA-IR, BMI and WHR. There was not significant correlation between CRP and HOMA-IR and also BMI.

Conclusion: The effect of metformin on reduction of serum ferritin was not significant just in obese group and was not associated with metabolic and anthropometric indexes.


Ferritin Polycystic Ovary Syndrome Metformin

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