Maternal and Prenatal Risk Factors for Childhood Leukemia in Southern of Iran


J Hassanzadeh 1 , R Mohammadi 1 , AR Rajaeefard 1 , MR Bordbar 2 , * , M Karimi 1

1 Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Fars, Iran

2 Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, [email protected], Fars, Iran, PO Box: 71937-11351

How to Cite: Hassanzadeh J, Mohammadi R, Rajaeefard A, Bordbar M, Karimi M. Maternal and Prenatal Risk Factors for Childhood Leukemia in Southern of Iran, Iran Red Crescent Med J. Online ahead of Print ; 13(6):398-403.


Iranian Red Crescent Medical Journal: 13 (6); 398-403
Article Type: Research Article
Received: November 12, 2010
Accepted: January 10, 2011




Background: The causes of childhood leukemia as the most common malignancy in children are vastly unknown. The aim of this study is to evaluate the relationship between maternal birth characteristics with environmental exposures in childhood leukemia.

Methods: This is a case-control study which consists of children younger than 18 years old suffering from leukemia who reside at Fars Province of Iran. Patients were individually matched with variables such as age, sex and residence region. In order to evaluate the relationships between each variable and the risk of leukemia, odds ratio(OR)  and 95% confidence interval (CI)  were estimated using conditional logistic regression.

Results: Statistically, the association between risk of childhood leukemia with birth order (OR=6.177, 95%CI: 2.551-14.957), pet ownership (OR=2.565, 95%CI: 1.352-4.868) and history of leukemia in first and second degree relatives (OR=2.667, 95%CI: 1.043-6.815) was significant. However, there was no significant association between daycare attendance, history of miscarriage, number of siblings and history of mother's diagnostic radiology tests with risk of childhood leukemia.

Conclusion: Although no definite etiologic factor for acute childhood leukemia has been clearly defined, the contribution of environmental risk factors in the context of genetic predisposition are strongly elucidated.


Leukemia Children Risk factors Prenatal Genetics

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