The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat

AUTHORS

K Rastegar 1 , H Roosta 1 , A Zarifkar 2 , * , A Rafati 1 , M Moosavi 1

1 Shiraz Neuroscience Research Center and Department of Physiology, Shiraz University of Medical Sciences, Fars, Iran

2 Department of Physiology, Shiraz University of Medical sciences, [email protected], Fars, Iran

How to Cite: Rastegar K, Roosta H, Zarifkar A, Rafati A, Moosavi M. The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat, Iran Red Crescent Med J. Online ahead of Print ; 13(5):316-322.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 13 (5); 316-322
Article Type: Research Article
Received: June 10, 2010
Accepted: September 27, 2010

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Abstract

Background: Reports on agmatine are controversial showing that it may improve memory, it can deteriorate memory and some did not notice any interference with learning and memory. In the present study, the effect of directly intra-CA1 agmatine microinjection on water maze learning and memory has been assessed.

Methods: The cannuls were implanted in hippocampal CA1 regions of rats in a sterotaxic frame after general anesthesia. After one week recovery period, the animals were assessed in the reference memory version of water maze. Agmatine (1, 10, 100 or 200 µg/0.5 µl) or saline were infused 20 minutes before or immediately after training.

Results: Agmatine-treated rats did not show any significant difference neither in water maze acquisition nor in consolidation task in comparison with control and sham groups. Conclusion: Agmatine does not affect water maze learning and memory.

Conclusion: Agmatine does not affect water maze learning and memory.

Keywords

Agmatine Water maze Learning Memory Hippocampus CA1 Rat

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