Association between TNF-Alpha (-857) Gene Polymorphism and Susceptibility to Tuberculosis


S Anoosheh 1 , * , P Farnia 2 , M Kargar 3

1 Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, [email protected], Tehran, Iran

2 Mycobacteriology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Iran

3 Department of Microbiology, Islamic Azad University, Jahrom Branch, Fars, Iran

How to Cite: Anoosheh S, Farnia P, Kargar M. Association between TNF-Alpha (-857) Gene Polymorphism and Susceptibility to Tuberculosis , Iran Red Crescent Med J. Online ahead of Print ; 13(4):243-248.


Iranian Red Crescent Medical Journal: 13 (4); 243-248
Article Type: Research Article
Received: September 10, 2010
Accepted: November 15, 2010




Background: TNF-α as a pro-inflammatory cytokine play a key role in host defense against tuberculosis (TB). Presence of mutation in TNF-α gene can influence the effectiveness, performance and capability of immune responses against this infection. The Aim of this study was to investigate the frequency of TNF-α alleles and its relationship with susceptibility to TB and TNF-α gene variations.

Methods: A case-control study was conducted and 103 healthy controls and 93 TB patients were enrolled. Genotype of TNF-238, TNF -244, TNF-308, TNF -857 and TNF-863 were distinguished using PCR-RFLP method.

Results: TNF-857 and TNF-863 were in high frequency mutation regions in a population level, and a significant difference at TNF-857 was noticed between the two groups of case and control .

Conclusion: Presence of mutation in TNF-857 region probably increases the host susceptibility to mycobacterial infection. Genotyping of these regions in combination with other factors can be used for screening of high risk persons. According to high distribution of mutations in TNF-857 and TNF-863 regions, further studies on association of these regions is suggested.


Tuberculosis TNF-? Gene Polymorphism

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