Initial Presentation of Acute Lymphoblastic Leukemia with Osteoporosis and Multiple Spontaneous Bone Fractures

AUTHORS

N Cohan 1 , S Sarikhani 1 , S Moslemi 1 , M Karimi 2 , *

1 Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, Iran

2 Professor of Pediatric Hematology-Oncology, Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, [email protected], Fars, Iran

How to Cite: Cohan N, Sarikhani S, Moslemi S, Karimi M. Initial Presentation of Acute Lymphoblastic Leukemia with Osteoporosis and Multiple Spontaneous Bone Fractures, Iran Red Crescent Med J. Online ahead of Print ; 13(1):52-54.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 13 (1); 52-54
Article Type: Case Report
Received: June 20, 2010
Accepted: August 28, 2010

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Abstract

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different factors including the disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate, corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse effect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of the disease.

Keywords

Acute lymphoblastic leukemia Osteoporosis Bone fracture Iran

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