Simultaneous Pattern Visual Evoked Potential and Pattern Electroretinogram in Strabismic and Anisometropic Amblyopia


J Heravian 1 , * , R Daneshvar 2 , F Dashti 2 , A Azimi 2 , H Ostadi Moghaddam 2 , AA Yekta 2 , H Esmaily 2

1 Department of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Malek Abad Square, [email protected], Razavi Khorasan, Iran

2 Eye Research Center, Khatam Anbia Hospital, Mashhad University of Medical Sciences, Razavi Khorasan, Iran

How to Cite: Heravian J, Daneshvar R, Dashti F, Azimi A, Ostadi Moghaddam H, et al. Simultaneous Pattern Visual Evoked Potential and Pattern Electroretinogram in Strabismic and Anisometropic Amblyopia, Iran Red Crescent Med J. Online ahead of Print ; 13(1):21-26.


Iranian Red Crescent Medical Journal: 13 (1); 21-26
Article Type: Research Article
Received: June 10, 2010
Accepted: August 18, 2010




Background: Amblyopia is a relatively common condition in which visual acuity through an eye is subnormal despite no overt pathology. Pattern visual evoked potential (PVEP) can detect any defect from optic nerve to occipital cortex and pattern electroretinogram (PERG) can detect retinal defects specially the ganglion layers. This study was performed to evaluate the cortical and retinal activity in strabismic and anisometropic amblyopia.


Methods: PVEP and PERG were recorded simultaneously in 40 amblyopes (20 strabismics and 20 anisometropics) and 20 normal control subjects. Normal subjects were age and sex matched with patients.


Results: The P100 latency in PVEP was increased in both groups of patients but the P100 amplitude was reduced only in anisometropic group. In PERG, the amplitude of P50 was reduced in all patients with no significant change in latency.


Conclusion: Beside reduced PVEP responses in strabismic and anisometropic amblyopia, the activity of retina reduced too. It is likely that retinal impulses can affect the development of visual system.


Strabismic amblyopia Anisometropic amblyopia PVEP PERG

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF