Differentiation of Fanconi and Aplastic Anemia Using Chromosomal Breakage Test in Southern Iran

AUTHORS

Sh Farjadian 1 , F Azad 1 , MR Bordbar 1 , M Karimi 2 , *

1 Department of Immunology, Shiraz University of Medical Sciences, Fars, Iran

2 Professor of Pediatric Hematology-Oncology, Hematology Research Center, Nemazee Hospital, Department of Pediatrics, Shiraz University of Medical Sciences, [email protected], Fars, Iran

How to Cite: Farjadian S, Azad F, Bordbar M, Karimi M. Differentiation of Fanconi and Aplastic Anemia Using Chromosomal Breakage Test in Southern Iran, Iran Red Crescent Med J. Online ahead of Print ; 10(4):323-325.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 10 (4); 323-325
Article Type: Brief Report
Received: April 2, 2008
Accepted: July 15, 2008

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Abstract

Background: Fanconi anemia (FA) is a chromosomal breakage disorder characterized by familial aplastic anemia (AA), various congenital anomalies, and a characteristic chromosomal response to clastogenic stress.

 

Methods: In this study, chromosome breakage test was performed for 38 patients suspected of having FA and age-matched controls.

 

Results: According to the results, ten patients were considered as FA cases and 15 patients with no chromosomal breaks were considered as AA.

 

Conclusion: Differentiation of FA from AA is very important because the primary treatment is different. This test should be done in every primary presentation of AA.

 

Keywords

Fanconi anemia Aplastic anemia Southern Iran

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