Distribution of Hepatitis C Virus Genotypes in Iranian Patients with Congenital Bleeding Disorders

AUTHORS

M Keshvari 1 , SM Alavian 2 , * , B Behnava 1 , SM Miri 1 , P Karimi Elizee 1 , SV Tabatabaei 1 , S Amini Kafi-Abad 1 , H Abolghasemi 1 , KB Lankarani 3

1 Iranian Blood Transfusion Organization Research Centre (IBTO), Tehran, Iran

2 Baqiyatallah Research Center, Gastroenterology and Liver Diseases, Baqiyatallah Hospital, PO Box 14155-3651, [email protected], Tehran, Iran

3 Health Policy Research Center, Shiraz University of Medical Sciences, Fars, Iran

How to Cite: Keshvari M, Alavian S, Behnava B, Miri S, Karimi Elizee P, et al. Distribution of Hepatitis C Virus Genotypes in Iranian Patients with Congenital Bleeding Disorders, Iran Red Crescent Med J. Online ahead of Print ; 12(6):608-614.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 12 (6); 608-614
Article Type: Research Article
Received: September 2, 2010
Accepted: October 1, 2010

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Abstract

Background: Chronic hepatitis C virus (HCV) infection is the major cause of liver disease related morbidity and mortality in hemophilic patients who needs regular blood product administration. Although genotype of infecting HCV is one of the prime predictors of response to antiviral therapy however, its distribution in hemophilic patients is still unclear and just few studies with low sample sizes have investigated this issue. Therefore, in this study, we aimed to identify this distribution in 367 Iranian hemophilic patients.

 

Methods: Blood samples were received from 367 hemophilic patients with chronic hepatitis C detected during a nationwide screening program who referred to our center for therapeutic measures. HCV RNA viral load was detected using Amplicor test (Version 2). Genotyping was performed by genotype specific primers.

 

Results: HCV genotype distribution was 1a in 58%, 3a in 18.5%, 1b in 14.7%, 4 in 1.1%, 2 in 0.8% and mixed in 6.2% and finally 0.5% of isolates were non-typable. Serum liver enzymes were not associated with HCV viral load and genotypes. Patients with severe bleeding tendency had significantly lower serum liver enzymes than those with a mild bleeding tendency.

 

Conclusion: Genotype 1a followed by 3a and 1b were the most frequently detected HCV genotypes in Iranian hemophilic patients and there was no association between splenomegaly and viral markers and liver enzymes in these patients.

Keywords

Hemophilia HCV Genotype Congenital bleeding disorder Iran

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