Dedifferentiated Chordoma: A Case Report

AUTHORS

Negar Azarpira ORCID 1 , * , F Asadian 2 , S Torabinejad 2

1 Associate Professor of Transplant Research Center,Department of Pathology, Nemazee Hospital, Shiraz University of Medical Sciences, [email protected], Fars, Iran

2 Department of Pathology, Shiraz University of Medical Sciences, Fars, Iran

How to Cite: Azarpira N, Asadian F, Torabinejad S. Dedifferentiated Chordoma: A Case Report, Iran Red Crescent Med J. Online ahead of Print ; 12(5):579-581.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 12 (5); 579-581
Article Type: Case Report
Received: December 20, 2009
Accepted: April 12, 2010

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Abstract

Sarcomatous transformation (dedifferentiated chordoma) in chordoma is a very rare condition and has been emphasized as a distinct entity because of its more aggressive clinical course. Here we describe a case of dedifferentiated chordoma arising from the sacrococcygeal region of a 60-year-old man, in third tumor recurrence. This tumor showed features of sarcoma with areas more typical of chordoma The chordoma-like areas expressed cytokeratin, epithelial membrane antigen and S-100 protein in all tumor cells and the spindle-cell component exhibited vimentin positivity in all of them but negative for other markers. The results showed that the sarcomatous areas as seen in the recurrent chordoma lack epithelial cell features of chordoma and suggest the possibility of altered differentiation pathway of the tumor stem cell or emergence of a new malignant cell population within the recurrent tumor.

Keywords

Chordoma Dedifferentiated Sacroccocygeal

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