Document Type : Research articles

Authors

1 Associate Professor, MD, Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran

2 Assistant Professor, MD, Ph.D in Traditional Persian Medicine, Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Assistant Professor, MD, Ph.D in Traditional Persian Medicine, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Science, Sari, Iran

4 Department of Pharmacology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5 School of Traditional Medicine and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran

6 Assistant Professor, MD, Ph.D in Traditional Persian Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Gastro-esophageal reflux disease (GERD) is one of the most widespread gastrointestinal disorders. In addition, there is increasing evidence that not all patients respond to its current remedies.
Objectives: The aim of this pilot study was to investigate the effect of “Satureja hortensis L.” on improving the symptoms of mild to moderate GERD in adults. Methods: In this double-blind, randomized, controlled clinical trial, we evaluated the efficacy of “Satureja hortensis L.” compared to placebo on the symptoms of GERD in fifty-eight adults with GERD who referred to Hazrat Rasool-e-Akram hospital in Tehran, Iran, in 2015. In order to assess GERD symptoms, a standardized questionnaire of frequency scale (FSSG) was used before and after the intervention. Results: Regarding within-group changes, a significant decrease was observed in FSSG, dysmotility-like symptoms and acid reflux
related scores in both groups of the study after the intervention compared to baseline (P < 0.001). Regarding between-group anal- ysis, no significant differences were observed between the two groups in terms of FSSG total scores (0.05 < P). Conclusions: According to the results of the current study, Satureja hortensis L. with the dose of 500 mg three times per day failed to improve the symptoms of GERD in adults compared to placebo. The significant reductions in the GERD scores in both groups seem to be related to the lifestyle modification that was prescribed to both groups

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