Document Type : Review articles


1 Department of Surgery, College of Medicine, Jouf University, Sakaka, Saudi Arabia

2 Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt

3 Clinical Pathology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt

4 Clinical Pathology Department, Clinical Microbiology Unit, Faculty of Medicine, Cairo University, Giza, Egypt

5 Tropical Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

6 Medical Physiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt

7 Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

8 Diagnostic and Interventional Radiology Department, Theodor Bilharz Research Institute, Giza, Egypt

9 Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

10 Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt

11 Pediatric Department, King Abdelaziz University, Jeddah, Saudi Arabia

12 Dermatology Department, Ibn Sina Faculty of Medicine, Jeddah, Saudi Arabia

13 Medicinal Chemistry Department, Faculty of Pharmacy, Jouf University, Sakaka, Saudi Arabia ; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

14 Pharmacology Department, Medical College and Health Science Research Unit, Jouf University, Sakaka, Saudi Arabia


Although it was initially believed that the coronavirus disease 2019 (COVID-19) only attacked the respiratory system, reports over time demonstrated that this disease could attack the gastrointestinal tract (GIT) as well. The predominant presenting symptoms in patients infected with COVID-19 were gastrointestinal (GI), resulting in GI pathological changes. While clinicians concerns are mostly related to respiratory system manifestations, GI symptoms should be monitored and managed appropriately.
This review summarizes the essential information about COVID-19 GIT infection in terms of pathogenesis, major pathological changes, microbiological bases of infection, the possibility of feco-oral transmission, the severity of associated symptoms, the major radiological findings, the impact on GI surgery, the role of therapeutic agents in induction or magnification of GI symptoms, and a pitfall on the nutritional supplementation in COVID-19 patients.


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