Document Type : Research articles


1 Liver and Gastrointestinal Diseases Research Center, Tabriz Cystic Fibrosis Registry, Tabriz University of Medical Sciences, Tabriz, Iran

2 Tuberculosis and Lung Diseases Research Center, Iranian Cystic Fibrosis Patient Registry (IRCFPR ) Northwest Branch ,Tabriz University of Medical Sciences, Tabriz, Iran

3 Liver and Gastrointestinal Diseases Research Center, Department of Pediatrics, Tabriz University of Medical Sciences, Tabriz, Iran

4 Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran

5 Department of Surgery, Tabriz University of Medical Sciences, Tabriz, Iran


Background: Early diagnosis of cystic fibrosis (CF) and hence the initiation of symptomatic and prophylactic treatment can help improve the outcomes of CF patients. Fecal calprotectin (FC) is a marker of inflammation in the intestinal tract that is elevated in several gastrointestinal inflammatory diseases, but little is known about its value in CF.
Objectives: This study, therefore, aimed to survey the associations of FC among CF patients and its correlation with the clinical manifestations of CF.
Methods: This descriptive cross-sectional study was performed on 52 children with CF visiting the Childrens Hospital of Tabriz, Iran, during 2018-2019, selected through the census sampling method. The calprotectin values of <50 ?g/g were considered normal.
Results: There was no clinically relevant association among FC levels concerning pancreatic insufficiency, diabetes, and airway colonization with Pseudomonas. In a comparison of the number of exacerbations and Forced Expiratory Volume in the first second (FEV1), the levels of electrolytes showed no significant difference between patients with normal calprotectin and elevated FC. The results of the performed analysis indicated no significant difference between the low-fecal elastase and the FC levels in patients with CF (P=0.53).
Conclusion: Demographic and clinical parameters, such as age, gender, FEV1, or Body Mass Index, had no clinically significant relationship with FC. However, serial and longitudinal calprotectin levels should also be checked, which may have clinical relevance during symptomatic episodes.


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