Document Type : Research articles


1 Department of Endocrinology, Aerospace Center Hospital, Beijing, China

2 Department of Cardiovascular Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China


Background: There have been no studies investigating the association of serum calcium level upon admission with long-term cardiovascular outcome among patients suffering from acute coronary syndrome (ACS).  
Objectives: This study aimed to explore the correlation of serum calcium level upon admission with cardiovascular outcomes among ACS patients.
Methods: This longitudinal study included 105 ACS or suspected ACS patients who were referred to the Coronary Care Unit from June 1st, 2015, to August 31st, 2016. Serum calcium was measured upon admission, and the patients were followed up until November 30th, 2016. Cardiovascular death or cardiovascular re-hospitalization was the study's end.
Results: According to the median of serum calcium, the patients were divided into two groups of lower (n=47) and higher serum calcium level (n=58). The results of the Kaplan-Meier analysis revealed that patients with lower serum calcium obtained a significant decrease in cardiovascular event-free survival (log-rank ?2=5.594, P=0.018), compared to those with higher serum calcium level. Furthermore, lower serum calcium level (HR=0.265, 95% CI=0.072-0.981, P=0.047) independently correlated with poor cardiovascular outcome in ACS or suspected ACS patients after adjusting the potential confounders in the multivariable Cox model.
Conclusion: Lower serum calcium level upon admission independently correlated with poor long-term cardiovascular outcomes in patients with severe coronary artery disease.


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