Facilitation of Temozolomide Resistance of Glioblastoma by Long Noncoding RNA DLK1-35

Yuhui Li; Xuan Zheng; Dan Li; Mingyang Sun; Zhuo Wang; Jingwu Li; Yufeng Li

Volume 25, Issue 5 , 2023

Abstract
  Background: Long noncoding RNAs played critical roles in glioblastoma development. Objectives: This study aimed to examine the impacts of lncRNA DLK1-35 on glioblastoma cells and mice. Methods: Methyl Thiazolyl Tetrazolium (MTT) was applied for examining the viabilities of U87 and U251 cells, as well ...  Read More

Cost of Blood Products in Iran: A Case Study of the Shiraz Blood Transfusion Organization Using Activity-based Costing

Sulmaz Ghahramani; Leila Zarei; Leila Kasraian; Maryam Mollaie; Hengameh Kasraei; Kamran Bagheri Lankarani

Volume 25, Issue 6 , 2023

Abstract
  Background: Although blood is donated rather than purchased, collecting, storing, and testing it for viral markers is expensive. During the Cost of Blood Consensus Conference (COBCON), activity-based costing (ABC) was proposed as a standard way to figure out the cost of preparing a unit of blood. Objectives: ...  Read More

Safety of Omitting Preoperative Antibiotic Prophylaxis in Patients Undergoing Transurethral Ureterolithotripsy

Reza Falahatkar; Siavash Falahatkar; Ardalan Akhavan; Samaneh Esmaeili; Ehsan Kazemnezhad; Emad Moaied Abedi

Volume 25, Issue 7 , 2023

Abstract
  Background: Transurethral ureterolithotripsy (TUL) is a common and highly efficient procedure for treating ureteral stones. The need for preoperative antibiotic prophylaxis to prevent post-TUL infections remains controversial. Objectives: This study aimed to investigate whether the removal of preoperative ...  Read More

Inhibition of Cancer Stem Cells Growth with Silibinin Encapsulated in Nanoparticles with Deregulation of miR-34a, miR-221, and miR-222

Samaneh Hossainzadeh; Alireza Nouhi Kararoudi; Seyed Milad Mousavi Eshkelani; Safura Pakizehkar; Alireza Naderi Sohi; Farhood Najafi; Najmeh Ranji

Volume 25, Issue 4 , 2023

Abstract
  Background: Colorectal Cancer (CRC) is the most common malignant gastrointestinal cancer. Cancer stem cells (CSCs) are the major cause of cancer recurrence and cancer drug resistance. Silibinin, as an herbal compound, has anticancer properties. Objectives: The present study aimed to evaluate the antiproliferative ...  Read More

Construction of a Quality Evaluation system for Emergency Pre-examination and Triage under the Normalization of the COVID-19 Epidemic based on the SERVQUAL Model

Hongquan Fan; Zhe Chu; Huimin Li; Wei Wang

Volume 25, Issue 3 , 2023

Abstract
  Background: The effect of emergency epidemic prevention and control and the quality of emergency pre-testing and triage under the normalization of COVID-19 epidemics was evaluated by quality evaluation system based on the SERVQUAL model. Objectives: This study aimed to develop a quality evaluation system ...  Read More

Common Anesthesia Challenges in a Case of Ankylosing Spondylitis Posted for the Correction of Spinal Deformity

Arash Heroabadi; Reza Atef Yekta; Saleheh Asghari

Volume 25, Issue 7 , 2023

Abstract
  Background: Ankylosing spondylitis (AS) is a type of inflammatory arthritis. Due to the rigid and brittle nature of spinal joints and multisystem involvement in the patients affected by ankylosing spondylitis, they are more prone to developing various complications. Different deformities require several ...  Read More

Comparing the Impact of Multimedia and Educational Brochures on Knowledge, Attitude and Work Performance of Healthcare about COVID-19 Management in Pregnancy, Childbirth, and Breastfeeding

bahiye amiri

Volume 25, Issue 11 , 2023

Abstract
  Background: In times of pandemic and quarantine, it is necessary to use new educational methods. The aim of this study was to compare the effectiveness of multimedia and booklet educational methods on knowledge, attitude, and job performance of healthcare providers in community health centers regarding ...  Read More

Preoperative Hypoalbuminemia and Development of Surgical Site Infection and Anastomotic Leakage in Emergency Colorectal Surgery

Mohammad Pishgahi; Seyed Mohammad Reza Nejatollahi; Fariba Ghorbani; Sadra Montazeri

Volume 25, Issue 9 , 2023

Abstract
  Background: Although hypoalbuminemia is a well-known predictor of postoperative complications, including surgical site infection (SSI) and anastomotic leakage (AL) in gastrointestinal surgery patients, which requires necessary interventions before surgery, there is limited opportunity for preoperative ...  Read More

Clinicopathological Properties of Mesenchymal Tumors of the Stomach and Surgical Treatment Outcomes

U?ur Topal

Volume 25, Issue 6 , 2023

Abstract
  Background: Mesenchymal tumors are part of a heterogeneous group of neoplasms. Objectives: The present study investigated the clinicopathological properties and surgical outcomes of patients with gastric mesenchymal tumors who underwent surgical treatment. Methods: This study included all cases who underwent ...  Read More

In Silico and Experimental Outcomes of the Expression of miR508-5p and miR-635 in Tumor Tissues of Patients with Breast Cancer

Fatemeh Zeinali Sehrig; Mohammad Zaefizadeh; Changiz Ahmadizadeh; Mohammad Reza Alivand; Saeid Ghorbian

Volume 25, Issue 8 , 2023

Abstract
  Background: Breast cancer (BC) is a malignant tumor that occurs in the epithelial tissue of the breast gland and has become the most common malignancy in women. Various studies have reported the effect of epigenetic changes, including DNA methylation and microRNAs, on breast carcinogenesis. microRNAs ...  Read More

Efficacy of Modified Endoscopic Dacryocystorhinostomy in the Treatment of Chronic Dacryocystitis

Jiangxiong Cai; Qihong Chi

Volume 25, Issue 4 , 2023

Abstract
  Background: Untreated chronic dacryocystitis (CD) can lead to serious ocular complications. Objectives: This study aimed to analyze the efficacy of modified endoscopic dacryocystorhinostomy (DCR) in the treatment of CD and the effects on ocular surface, inflammatory response, and immune function of patients. Methods: ...  Read More

Pharmacogenetic Study of Drugs affecting Coronavirus

samira shabani; Massoud houshnamnd; tayebeh majidizade; samira sheibania

Volume 26, Issue 1 , 2024

Abstract
  A new worldwide pandemic of coronavirus disease 2019 (COVID-19) has resulted in a healthcare crisis with high mortality and morbidity. Presently, several drugs are under accelerated research without established efficacy and are being used to treat COVID-19 patients either as unapproved drug use or as ...  Read More

Laparoscopic Bilateral Adrenalectomy with the Transabdominal Lateral Approach

Mustafa Gok; Bahad?r Oz; Alper Akcan; Erdo?an Sozuer

Volume 25, Issue 8 , 2023

Abstract
  Background: Laparoscopic adrenalectomy (LA) is a widely accepted method for most adrenal lesions. However, bilateral LA is performed less often than unilateral adrenalectomy. The most common indication for bilateral LA is adrenocorticotropin hormone (ACTH)-dependent Cushings syndrome, including persistent ...  Read More

Evaluation of coagulopathy frequency and risk factors in trauma patients in intensive care unit

Melek Doganci; Firdevs Tugba Bozkurt; Ahmet Gokhan Akda?; Seval ?zde?

Volume 25, Issue 3 , 2023

Abstract
  Background: Post traumatic coagulopathy is a frequently encountered problem. However, risk factors related to coagulopathy are not exactly known. Objectives: In this study it is targeted to determine the frequency of coagulopathy related to trauma, risk factors and its affect to prognosis on patients ...  Read More

Effects of Self-perineal Care Education using a Mobile Application on Knowledge and Practice of Perineal Care among Primigravida Mothers: A Quasi-Experimental Study

Lilly Mary Lazarus; Chong Mei Chan; Vimala Ramoo; Noor Azmi Mat Adenan; Karuthan Chinna; Law Foong Li; Samira Mohajer

Volume 25, Issue 8 , 2023

Abstract
  Background: Poor self-perineal care (SPC) by new mothers due to inadequate knowledge can result in perineal pain and poor wound healing outcome. Objectives: This study aimed to evaluate the effectiveness of self-perineal care education on knowledge and practice among primigravida mothers in Malaysia. Methods: ...  Read More

Assessment of Clinical Features and Related Risk Factors in Patients with Pulmonary Embolism in a Tertiary Teaching Center

Marjan Akhavan; Omalbanin Paknejad; Seyedeh Zahra Fotook Kiaei; Mahnaz Pejman Sani

Volume 25, Issue 12 , 2023

Abstract
  Background: Pulmonary thromboembolism (PTE) is a common and potentially life-threatening disease with manifestations similar to many other diseases, including myocardial infarction, pericarditis, myocarditis, and pneumonia. The present study aimed to assess clinical symptoms, some paraclinical parameters, ...  Read More

Preoperative Anxiety and Postoperative Pain in Children with Burn Patients and Their Correlation Analysis

Wazhuoma Da

Volume 25, Issue 2 , 2023

Abstract
  Background: Burn is a kind of skin tissue damage under the influence of heat source, which is a common type of accidental injury in current society.Objective: To investigate the status of preoperative anxiety and postoperative pain in children with burn patients, and to analyze the correlation between ...  Read More

Evaluation of Optic Nerve Sheath Diameter by Computerized Tomography in the Detection of Early Stage Acute Ischemic Cerebrovascular Disease

yavuz selim Divriklioglu Divriklioglu; onur karakayal?; Yavuz Yi?it; serkan yilmaz; Yavuz Birinci; Bora kalaycioglu

Volume 25, Issue 10 , 2023

Abstract
  Introduction: Stroke is the leading cause of high mortality rates in the emergency department (ED). In this regard, early diagnosis and starting appropriate treatments are important. We aimed to evaluate the efficiency of the optic nerve sheath diameter (ONSD) in the detection of ischemic cerebrovascular ...  Read More

Evaluation of the Presence and Importance of PD-L1 Expression in Head-neck Squamosus Cell Carcinomas and Premalign Lesions

Ozlem Ceren Gunizi; Huseyin Gunizi

Volume 25, Issue 6 , 2023

Abstract
  Background: Programmed Death-Ligand 1 (PD-L1) is a cell membrane protein found on the surface of cancer cells, immune system cells in the tumor microenvironment, and various healthy tissues. Moreover, it plays a key role in suppressing the immune system. Objectives: We aim to explain the presence of ...  Read More

Sinonasal Cancer: A National Population-based Study in Iran

Matin Ghazizadeh; Fatemeh Hadavandsiri; Maryam Ghazizadeh; Mohammad Esmaeel Akbari

Volume 25, Issue 5 , 2023

Abstract
  Background: Cancer is a leading cause of death in the 21st century. Sinonasal malignancies comprise less than 0.5% of all cancers. There are limited epidemiologic studies on them. Objectives: The current study aimed to estimate the patient demographics, as well as the incidence rates of nasal cavity ...  Read More

Identification of the Gap in Pre-hospital Knowledge and Skills of the Red Crescent Society Rescuers of the Islamic Republic of Iran

Ahmad Soltani; Nader Ghanizadeh; Milad Ahmadi Marzaleh; Hadi Mahmoodi; Marjan Akbari

Volume 25, Issue 1 , 2023

Abstract
  Background: Natural and manmade disasters affect public health directly and indirectly. As statistics show, 31 of the 42 types of natural disasters in the world occur in Iran; therefore, preparation is necessary to effectively manage them. To this end, it is essential to train experienced and professional ...  Read More

Neurofibromatosis Type 1-Associated Multiple Malignant Peripheral Nerve Sheet Tumors: A Case Report and Literature Review

Parinaz Sedighi; Ahmad Raza Salim Bahrami; Arash Dehghan; Shiva Borzouei

Volume 25, Issue 5 , 2023

Abstract
  Background: Neurofibromatosis type 1 (NF-1) is a genetic disorder characterized by caf é-au-lait macules, freckling, Lisch nodules, and neurofibromas. NF-1 patients have a special predisposition to tumorigenesis due to genetic mutations, affecting the tumor regulator systems. Malignant Peripheral ...  Read More

Oncoplastic Techniques in Treatment of Central Breast Tumors: Oncological, Aesthetic, and Patient Satisfaction Outcomes

Mustafa Emiroglu; Huseyin Esin

Volume 25, Issue 11 , 2023

Abstract
  Background: The employment of oncoplastic techniques for the treatment of central breast cancer is becoming increasingly popular. Objectives: Our study aimed to evaluate the oncological safety of oncoplastic techniques in central breast cancer patients, and to assess resulting breast aesthetics and patient ...  Read More

Ultrasonography Techniques for Atherosclerosis Assessment: A Narrative Review

Lin Gan; Zhoupeng Wu

Volume 25, Issue 7 , 2023

Abstract
  Ultrasound is very important for the diagnosis and treatment of vascular emergency patients. In recent years, the number of deaths caused by atherosclerosis, represented by ischemic heart disease, has increased rapidly and become a very important part of emergency medicine. This article aimed to review ...  Read More

Pulmonary Fat Embolism Syndrome: A Case Report and Literature Review

Jingrun Zhou; Huaqin Pan; Yurui Wang; Zhen Zeng; Jiarui Zhang; Yumeng Cao; Guqin Zhang

Volume 25, Issue 7 , 2023

Abstract
  Background: Fat embolism syndrome (FES) is caused by a systemic inflammatory response arising from embolized fat particles that block blood vessels and disrupt blood supply, particularly in the respiratory microcirculation. Despite its high morbidity and mortality, FES is still challenging to diagnose ...  Read More