Effects of the Portulaca oleracea Extract on Gentamicin-Induced Nephrotoxicity in Male Rats

Mohammad Sadidi; Mahmood Bakhtiyari; Amirhesam Alirezaei

Volume 21, Issue 2 , February 2019, , Pages 1-7

  Background: Some data suggest the protective effect of Portulaca oleracea against renal failure and its association with the preser-vation of the renal antioxidant status and the regulation of apoptosis.Objectives: The current study aimed to examine the renoprotective effects of treatment with Portulaca ...  Read More

Protective Effects of Artemisia persica Essential Oil Against Pentylenetetrazol-Induced Seizure in Male Mice with Emphasizing Its Mechanism of Action

Mojgan Daneshkhah; Mahbubeh Setorki

Volume 21, Issue 2 , February 2019, , Pages 1-8

  Background: A new approach in the treatment of epilepsy is to use new drugs with neuroprotective, antioxidant, and anti-inflammatory effects.Objectives: The study aimed to investigate the protective effects of Artemisia persica essential oil (EO) against pentylenetetrazol(PTZ)-induced seizure in mice.Methods: ...  Read More

The Protective Effects of Cultured Mesenchymal Stem Cells onto the Surface of Electrospun Poly-L-Lactide Acid Scaffolds Coated with Matricaria Chamomilla L. Oil in Streptozotocin-Induced Diabetic Rabbits

Saeid Saghahazrati; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Bagher Minaei

Volume 21, Issue 2 , February 2019, , Pages 1-9

  Background: Although Matricaria chamomilla L. oil has been shown to contribute to the differentiation of mesenchymal stem cells(MSCs) into insulin-producing cells, the molecular mechanisms underlying its effect in the treatment of Type 1 Diabetes mellitus(T1DM) is still not available.Objectives: The ...  Read More

Pharmacokinetic Interaction Study for Simvastatin and Parsley and Its Plasma Quantification Using LC-MS: A Focus on Drug Metabolic Enzymes

Rizwan Ahmad; Niyaz Ahmad; Dhafer Mahdi Alshayban; Muntathir Ali Alamer; Ali Hassan Mohammed Alkhalifah; Hamzah Mohammed Almomatten

Volume 21, Issue 2 , February 2019, , Pages 1-9

  Background: Parsley (Petroselinum crispum L) (PAR) is used widely as an antioxidant, antihyperlipidemic, diuretic, and medicationto reduce hypertension. At the same time, conventional drugs such as Simvastatin (SV) are also used to manage hyperlipidemia inhypertensive patients. However, no studies have ...  Read More

Disasters; The Opportunity of Reconstruction and Development: The Successful Experience of the 2017 Kermanshah Earthquake

Davoud Pirani; Kosar Yousefi; Ali Sahebi

Volume 21, Issue 2 , February 2019, , Pages 1-1

  An earthquake measuring 7.3 on the Richter struckEzgeleh in Kermanshah province on November 12, 2017,at 21:48 local time. In this devastating event, around4,700,000 individuals were involved, 650 cases of deathand around 8000 injuries were reported, as well as 70.000individuals were made homeless.   Read More

Successful Treatment of Heart Failure Due to Simultaneous Poisoning with Aluminum Phosphide and Zinc Phosphide: A Case Report

Aliasghar Manouchehri; Reza Mohseni Ahangar; Pedram Bigvand; Samaneh Nakhaee; Omid Mehrpour

Volume 21, Issue 3 , March 2019, , Pages 1-6

  Introduction: Rodenticides are considered a global challenge to public health. Two major compounds in this category includealuminum phosphide and zinc phosphide. However, the simultaneous use of aluminum phosphide and zinc phosphide has notbeen reported in the literature.Case Presentation: We present ...  Read More

An Unusual Ring-Shaped Gallstone Mimicking Porcelain Gallbladder in a Patient with Chronic Kidney Disease: A Case Report

Shang-Feng Tsai; Jun-Li Tsai

Volume 21, Issue 3 , March 2019, , Pages 1-4

  Background: Porcelain gallbladder is associated with a higher prevalence of malignancy. Prophylactic cholecystectomy is sug-gested for both symptomatic and asymptomatic patients. Although gallstones are very commonly observed in clinical practices, itis recommended in asymptomatic patients. However, ...  Read More

Application of the One-Stop Cardiac CT Scan on 256-Row Wide Detector Revolution CT in Myocardial Ischemia of Aortic Valve Degeneration Diagnosis

Xuefang Lu; Wei Gong; Yunfei Zha

Volume 21, Issue 3 , March 2019, , Pages 1-9

  Background: Advances in Imaging has been used increasingly to assess coronary lumen and myocardial perfusion with more ac- curacy.Objectives: The aim of this study was to evaluate the diagnostic performance of one-stop cardiac CT myocardial perfusion imaging (CT-MPI) combined with coronary artery CT ...  Read More

Effect of Peppermint Oil on Premenstrual Syndrome: A Randomized, Double-Blind Placebo-Controlled Study

Mouloud Agajani Delavar; Soheila Ebrahimi; Sedigheh Esmaeilzadeh; Azam Khamse

Volume 21, Issue 3 , March 2019, , Pages 1-8

  Background: Despite the mental, physical, and behavioral problems of premenstrual syndrome (PMS) in reproductive women, there is no general agreement on effective treatment.Objectives: To determine the safety and effectiveness of herbal medicine capsules of peppermint oil as a novel formulation used ...  Read More

Anti-Proliferative Effects of Two New Lactobacillus Strains of Human Origin on Caco-2 Cell Line

Simin Arian; Hami Kaboosi; Zaheir Heshmatipour; Zeinab Khazaei Koohpar; Fatemeh Pyravii-Ghadikolaii

Volume 21, Issue 3 , March 2019, , Pages 1-8

  Background: Anti-proliferative effects of probiotics are considerable in the treatment of various cancers, including colon cancer. In the present study, two new Lactobacillus strains as probiotics were isolated from stool samples at a clinical lab.Objectives: The aim of this study was to evaluate the ...  Read More

Identification of CDKN3 and UBE2C mRNAs as Prognostic Biomarkers in Early-Stage Lung Adenocarcinoma Using Bioinformatics Strategy

Qiang Chen; Lutong Xu; Jing Hu; Tonglian Wang; Kang Zhang; Hongbo Zhao; Yuanyue Li; Tao Shou

Volume 21, Issue 3 , March 2019, , Pages 1-10

  Background: Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer with very poor 5-year overall survival (OS) rate. It is histopathologically difficult to predict clinical outcome in early-stage LUAD. Identifying reliable prognostic biomarker is absolutely critical ...  Read More

The Protective Effect of Hydroalcoholic Extract of the Southern Maidenhair Fern (Adiantum capillus-veneris) on the Depression and Anxiety Caused by Chronic Stress in Adult Male Mice: An Experimental Randomized Study

Jafar Ahmadpoor; Saeid Valipour Chahardahcheric; Mahbubeh Setorki

Volume 21, Issue 3 , March 2019, , Pages 1-8

  Background: Antioxidant compounds are novel approaches in the treatment of neurological disorders.Objectives: The purpose of this study was to examine the antidepressant and anxiolytic effects of the hydroalcoholic extract of Adiantum capillus-veneris (rich in flavonoids with antioxidant properties) ...  Read More

Effect of Serum Hepcidin on Predicting Mortality in Hemodialysis Patients: A Prospective Cohort Study

Ling Sun; Lu-Xi Zou; Yan Lu; Na Deng; Hui-Xin Wang

Volume 21, Issue 3 , March 2019, , Pages 1-7

  Background: Hepcidin is a key regulator of iron homeostasis, while the clinical utility of hepcidin remains uncertain in hemodial- ysis (HD) patients.Objectives: Our study aimed to evaluate the predictive effect of serum hepcidin-25 on mortality in HD patients.Methods: A prospective observational cohort ...  Read More

Mutation in KRAS and BRAF Genes in Helicobacter pylori-Infected Patients with Gastric Cancer and Peptic Ulcer

Khatoon Heidari; Hami Kaboosi; Ailar Jamali; Ezzat Allah Ghaemi; Fatemeh Peyravii Ghadikolaii

Volume 21, Issue 3 , March 2019, , Pages 1-6

  Background: Helicobacter pylori are the main cause of various gastroduodenal diseases. It is estimated that approximately half of the planet population is infected with H. pylori. KRAS and BRAF genes are the targets of genetic changes in H. pylori-infected patients with gastric cancer (GC) and peptic ...  Read More

Lessons Learned from the 2017 Kermanshah Earthquake: The Presence of Celebrities in the Field

Alireza Mashallahi; Milad Ahmadi Marzaleh; Abbas Ostadtaghizadeh

Volume 21, Issue 3 , March 2019, , Pages 1-2

  Ezgeleh is a city in Kermanshah province, in western Iran. According to the census 2016, the city populationwas 1502 individuals. At 21:48 PM on the 12th of Novem- ber 2017, an earthquake with a magnitude of 7.3-RichterScale struck the city at the depth of 11-kilometer. The epi- center was in Ezgeleh, ...  Read More

Coincident of Gastrointestinal Stromal Tumor and Two Other Primary Malignancies: A Case Report

Touraj Asvadi Kermani; Farzad Kakaei; Kowsar Tarvirdizade

Volume 21, Issue 10 , October 2019, , Pages 1-8

  Background: Methamphetamine dependence is a growing global problem. Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence. One of the alternatives to manage this addiction is the use of N acetylcysteine (NAC) due to its capacity to restore homeostasis ...  Read More

Effect of Selenium Added to the Cardioplegic Solution on Cardiac Protection in Coronary Artery Bypass Grafting Surgeries: A Randomized, Double-Blinded, Clinical Trial Study

Masih Shafa; Simin Azemati; Masood Abasi; Rahim Hemati

Volume 21, Issue 10 , October 2019, , Pages 1-7

  Background: Coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) triggers an inflammatory reaction, leading to the development of myocardial damage and dysfunction. Selenium is the main cofactor for many antioxidant enzymes.Selenium level is decreased during heart surgeries affecting ...  Read More

Silymarin in Preventing Anti-Tuberculosis and AntipsychoticDrug-Induced Liver Injury at Different Doses and Treatment Times: A Systematic Review

Ying Kun Sheng; Lu Zhang; Yin Hong

Volume 21, Issue 10 , October 2019, , Pages 1-9

  Context: The therapeutic effect, the optimal treatment time, and the dose of silymarin for preventing anti-tuberculosis and antipsy- chotic drug-induced liver injury (anti-TB/antipsychotic DILI) remains controversial. We conducted the first systematic review and meta-analysis study to evaluate the clinical ...  Read More

Prevalence of PTSD Symptoms Among Iranian Red Crescent Disaster Workers Participated in Rescue and Collection Operation of the Tehran - Yasuj Airplane Crash

Shirali Kheramin; Iman Shakibkhah; Majid Ashrafganjooie

Volume 21, Issue 10 , October 2019, , Pages 1-8

  Background: The airplane crash is one of the most catastrophic events that may lead to extensive damage. The Tehran - Yasuj air- plane crash was one of these disasters that took place on 18 February 2018 in Dena mountains in the south of Iran and resulted in the death of all 66 passengers and staff.Objectives: ...  Read More

Antidepressant and Anxiolytic Effect of Echium amoenum in Restraint Stress Model: The Role of Neuroinflammation in the Prefrontal Cortex and Hippocampus

Mohammad Nouri; Fereshteh Farajdokht; Mohammadali Torbati; Fatemeh Ranjbar; Sanaz Hamedyazdan; Saeed Sadigh-Eteghad; Mostafa Araj-Khodaei

Volume 21, Issue 10 , October 2019, , Pages 1-14

  Background: Echium amoenum (E. amoenum) is an Iranian medicinal plant with mood-enhancing effects.Objectives: This study was designed to investigate the effect of standardized E. amoenum hydroalcoholic extract on restraint stress (RS)-evoked anxiety- and- depressive-like behaviors in mice.Methods: This ...  Read More

Monoclonal Antibody Preparation Against Nucleoprotein of Avian Influenza Virus Subtype H9N2

Maryam Hashemi; Rasool Madani; Mahmoudreza Aghamaali; Tara Emami; Fariba Golchinfar

Volume 21, Issue 10 , October 2019, , Pages 1-8

  Background: In recent years, various poultry diseases have posed risks to this industry. Respiratory and infectious diseases are the most common diseases. According to previous findings, influenza disease is recognized as a significant life-threatening disease in the industry of poultry worldwide. Influenza ...  Read More

Purification of Nucleoprotein of H9N2 Avian Influenza Virus Strain by Electroelution

Maryam Hashemi; Mahmoudreza Aghamaali; Rasool Madani; Tara Emami

Volume 21, Issue 10 , October 2019, , Pages 1-5

  Background: Avian influenza virus (AIV) belongs to the family of Orthomyxoviruses type A and causes avian influenza (AI) infectious disease. Currently, serological diagnostic techniques such as agar gel propagation (AGP), hemagglutination inhibition, and enzyme- linked immunosorbent assay (ELISA) are ...  Read More

Acute Bacterial Parotitis in Early Infancy: A Case Report and Review of the Literature

Mahmoud Soltani; Asma Javid

Volume 21, Issue 10 , October 2019, , Pages 1-4

  Introduction: Acute parotitis is known as an uncommon disease in children and a rare condition in infancy. Dehydration, pre- maturity, immune deficiency, congenital anomalies of the parotid gland or ducts, and oral trauma are some of its important risk factors. The most common bacteria contributing to ...  Read More

Phytochemical Contents of Salvia grossheimii SOSN. Species Extract and Its Protective Effect on Alcohol-Induced Fatty Liver in Rats

Seyed Morteza Hosseini; Mostafa Asadbegy; Roya Karamian; Siamak Yari

Volume 21, Issue 11 , November 2019, , Pages 1-7

  Background: Researchers are interested in finding new agents with natural sources to cure oxidant-induced diseases.Objectives: The study aimed at determining the antioxidant potential and protective effect of S. grossheimii extract against alcohol- induced fatty liver.Methods: This experimental study ...  Read More

Protective Effects of Antioxidant Supplements on Sperm Parameters, Sperm DNA Damage and Level of Seminal ROS in RPL Patients: A Clinical Trial Study

Soheila Pourmasumi; Nasrin Ghasemi; Alireza Talebi; Jalal Ghasemzadeh; Parvin Sabeti

Volume 21, Issue 11 , November 2019, , Pages 1-8

  Background: Recurrent Pregnancy Loss (RPL) is an important medical problem comprising approximately 15% of all pregnancies. Sperm DNA damage and level of seminal ROS may have a role in RPL.Objectives: The main aim of the present study was to appraise the efficacy of antioxidants for improving these parameters ...  Read More