Experimental Study on the Anti-tumor and Pro-apoptotic Effects of Paeonol in Human Gliomas

Qiang Fu; Dong Hai Liu; Zi Xuan Li; Xiao Peng Zheng; Cynthia Mutemwa; Elvis Agbo

Volume 25, Issue 4 , 2023

Abstract
  Background: Current studies have demonstrated the anti-cancer effects of paeonol in some tumors; however, its effect on gliomas remains unknown. Objectives: This study aimed to investigate the anti-tumor effect of paeonol in human glioma tissues and cells including its effect and connection with apoptosis ...  Read More

Anti-tumor Effect of the Ethanolic Extract of Vinca herbacea on Human Breast Cancer Cell Line: A Mechanism Study

Somayeh Dehghanipour; Sara Saadatmand; Nasim Hayati Roodbari; Mahdi Mahdavi

Volume 24, Issue 8 , 2022

Abstract
  Background: Breast cancer is extensively studied for its resistance to chemotherapy. Therefore, finding efficient therapeutic agents is vital to increasing the survival rate of patients. Objectives: Here, we conducted an in vitro study on the anti-tumor properties of Vinca herbacea extract on SKBR3 ...  Read More

Investigation of the Apoptotic Effect of Levofloxacin on Ovarian Follicles of NMRI Mice and its Anticancer Effect on Human Ovarian Cancer Cell Line

Sedigheh Sadat Borhani; Nasim Hayati Roodbari; Nasrin Heidarieh; Kambiz Roshanaei

Volume 24, Issue 7 , 2022

Abstract
  Background: Levofloxacin is a fluoroquinolone antibiotic with extensive anti-bacterial effects. Levofloxacin is widely used for treatment of urinary and vaginal infections. Objectives: This research surveyed the cytotoxicity effects of levofloxacin on ovarian follicles of mice in both in vitro and in ...  Read More

Evaluation of the Silver Graphene Quantum Dot Effect when Combined with Resveratrol and Radiation in Colorectal Cancer Cells

saba alidadi; mahshid mohammadian; reza zohdiaghdam; kosar esgandari; zhaleh behrouzkia

Volume 24, Issue 2 , 2022

Abstract
  Background: Colorectal cancer (CRC) is one of the major leading causes of cancer related death throughout the world. Among various therapeutic strategies for CRC, neoadjuvant radiotherapy, targeted therapy, and chemotherapy are the main techniques to destroy cancerous cells. Objectives: The main purpose ...  Read More

Assessment of the Regulatory Effect of Novel Indole-Core-Based Compound on Apoptosis and Cell Survival of Acute Myeloid Leukemia Cell Line

Parisa Heydari; Mojgan Noroozi-Karimabad Noroozi-Karimabad; Zahra Sheikh rezaee; Ali Darekordi; Maryam Fekri Soofi Aadi; Ahmad Fatemi; Gholamhossein Hasanshahi

Volume 23, Issue 8 , 2021

Abstract
  Background: Heterocyclic compounds are generally introduced as important valuable sources of pharmacologically active compounds. Amongst these compounds, the indole is largely distributed within the bioactive molecules, containing antitumor agents. Due to their unique physiochemical and biological properties, ...  Read More

Cardioprotective role of myocardial endothelial nitric oxide synthase and serum nitric oxide induced by hexarelin in rats with myocardial infarction-induced heart failure

Elvis Agbo; Dong Hai Liu; Jia Wan Liao; Roland Osei SAAHENE; Precious Barnes

Volume 23, Issue 6 , 2021

Abstract
  Background: Growth hormone-releasing peptides (GHRP) have been reported to possess cardioprotective properties; nonetheless, their mechanisms of action are still not very clear. Objectives: Some studies have suggested that modulation of endothelial nitric oxide synthase (eNOS) and the upregulation of ...  Read More

Quercetin Increases Doxorubicin-Induced Apoptosis Through Oxidative DNA Damage in KATO III Gastric Cancer Cells

Mingxiang Chen; Chunxiao Duan; Jun Pan

Volume 23, Issue 4 , 2021

Abstract
  Background: Gastric cancer is the most common gastrointestinal malignancy with an increasing incidence rate worldwide. Finding novel curative and preventive approaches that could target the tumor cells without affecting the normal cells and overcome drug resistance will be tremendously useful. Objectives: ...  Read More

Effect of mir-129 on the Sensitivity Enhancement of Methotrexate and Migration Inhibition in Osteosarcoma Cancer Cells

Junxue Wu; Chao Zhang; Lin Zheng; Lu Chen

Volume 23, Issue 2 , 2021

Abstract
  Background: MicroRNAs have been recently declared to be contributed to the various aspects of osteosarcoma cells, including growth and survival, apoptosis, invasion, and chemoresistance. Objectives: The present study aimed to investigate the potentiating effects of miR-129 on the chemosensitivity of ...  Read More

Promotion of Extrinsic Apoptosis Pathway in HCT-116 Human Colorectal Cancer Cell Line by Sodium Butyrate as Histone Deacetylase Inhibitor

Ainaz Mashayekhi; Flora Forouzesh; Mohammadreza Mashayekhi

Volume 23, Issue 1 , 2021

Abstract
  Background: Colorectal cancer (CRC) has already been considered the fourth leading cause of mortality worldwide as the genes involved in apoptotic pathways and alterations of reversible epigenetic have an important role in the progression of CRC.      Objectives: The current study ...  Read More

Effect of Elettaria cardamomum essential oil and its main component (1, 8?cineole) on brain damage caused by cerebral hypoperfusion by suppressing apoptosis and inflammation in rats

Mehrdad Farivar; Zahra Hooshmandi; Mahbubeh Setorki; Sabrieh Amini

Volume 22, Issue 12 , 2020

Abstract
  Background: Stroke is one of the most common causes of death in industrialized countries and a leading cause of permanent disability in adults worldwide. Elettaria cardamomum is a widely used nutraceuticalis, which is reported to have diverse functions, including positive effects on anxiety-like behavior properties. Objective: ...  Read More

miR-214 sensitizes human colorectal cancer cells to doxorubicin by p53 targeting

Li Wang; Peng Jiang; Chenhui Qu; Xuefeng Li; Lei Wang; Chunhong Wei

Volume 22, Issue 12 , 2020

Abstract
  Objectives: This study aimed to investigate the potential function of miR-214 in the apoptosis induction by targeting p53 in human colorectal cancer cells (CRC) in combination with doxorubicin (DOX). Methods: miR-214 mimics were transfected to HT-29 CRC cells. Following that, the transfected cells ...  Read More

SiRNA-mediated lncRNA ANRIL knockdown enhances the sensitivity of gastric cancer cells to doxorubicin

Jiahai Chen; Xuejiang Dai; Hebin Yu; Fei Pe; Lina Chen

Volume 22, Issue 10 , 2020

Abstract
  Background: Long non-coding RNAs (lncRNAs) play pivotal roles in carcinogenesis and the development of drug resistance in various malignancies. Objectives: The current study aimed to explore the impact of antisense non-coding RNA in the INK4 locus (ANRIL) silencing on proliferation and the sensitivity ...  Read More

Effect of Adenosine Injection Following Cerebral Reperfusion Ischemia on A1AR Gene Expression and Apoptosis in Brain Hippocampal Tissue of Male Wistar Rats

Atossa Jozaei; Monireh Movahedi; Maryam Khosravi; Fereshteh Golab

Volume 21, Issue 12 , 2019, Pages 1-8

Abstract
  Background: Apoptosis is a programmed cell death that occurs due to various factors such as reperfusion ischemia. As a purinergic receptor, A1AR acts as an oxidative stress sensor and an antioxidant during reperfusion ischemia.Objectives: The purpose of the present study was to investigate the effect ...  Read More

Effects of the Portulaca oleracea Extract on Gentamicin-Induced Nephrotoxicity in Male Rats

Mohammad Sadidi; Mahmood Bakhtiyari; Amirhesam Alirezaei

Volume 21, Issue 2 , 2019, Pages 1-7

Abstract
  Background: Some data suggest the protective effect of Portulaca oleracea against renal failure and its association with the preser-vation of the renal antioxidant status and the regulation of apoptosis.Objectives: The current study aimed to examine the renoprotective effects of treatment with Portulaca ...  Read More