Effect of Livergol on the Liver Function and its Histopathological Changes in Doxorubicin-Treated Rats

Marzieh Niakan; Habibollah Johari; Mehrdad Shariati

Volume 25, Issue 1 , 2023

  Background: Doxorubicin (DOX) is an effective anti-cancer medicine with serious side effects on healthy organs, especially the liver. Objectives: The present study aimed to investigate the histopathology and effects of Livergol (Liv), a product of Silybum marianum, on serum levels of hepatic parameters ...  Read More

Effect of Melatonin on Reversing Multidrug Resistance by Targeting Phosphatase and Tensin Homolog in Leukemia Cancer Cells

Vahid Rameshknia; Moireh Movahhedi; Abbas Akhavan; Maryam Majidinia; Bahman Yousefi

Volume 23, Issue 7 , 2021

  Background: Recently, melatonin has attracted massive attention due to its anticancer effect on various human malignancies. It has also been demonstrated that melatonin is useful in combating resistance against conventional chemotherapeutics. Objectives: This study aimed to evaluate melatonins effects ...  Read More

Quercetin Increases Doxorubicin-Induced Apoptosis Through Oxidative DNA Damage in KATO III Gastric Cancer Cells

Mingxiang Chen; Chunxiao Duan; Jun Pan

Volume 23, Issue 4 , 2021

  Background: Gastric cancer is the most common gastrointestinal malignancy with an increasing incidence rate worldwide. Finding novel curative and preventive approaches that could target the tumor cells without affecting the normal cells and overcome drug resistance will be tremendously useful. Objectives: ...  Read More

miR-214 sensitizes human colorectal cancer cells to doxorubicin by p53 targeting

Li Wang; Peng Jiang; Chenhui Qu; Xuefeng Li; Lei Wang; Chunhong Wei

Volume 22, Issue 12 , 2020

  Objectives: This study aimed to investigate the potential function of miR-214 in the apoptosis induction by targeting p53 in human colorectal cancer cells (CRC) in combination with doxorubicin (DOX). Methods: miR-214 mimics were transfected to HT-29 CRC cells. Following that, the transfected cells ...  Read More

SiRNA-mediated lncRNA ANRIL knockdown enhances the sensitivity of gastric cancer cells to doxorubicin

Jiahai Chen; Xuejiang Dai; Hebin Yu; Fei Pe; Lina Chen

Volume 22, Issue 10 , 2020

  Background: Long non-coding RNAs (lncRNAs) play pivotal roles in carcinogenesis and the development of drug resistance in various malignancies. Objectives: The current study aimed to explore the impact of antisense non-coding RNA in the INK4 locus (ANRIL) silencing on proliferation and the sensitivity ...  Read More