Effect of mir-129 on the Sensitivity Enhancement of Methotrexate and Migration Inhibition in Osteosarcoma Cancer Cells

Junxue Wu; Chao Zhang; Lin Zheng; Lu Chen

Volume 23, Issue 2 , 2021

  Background: MicroRNAs have been recently declared to be contributed to the various aspects of osteosarcoma cells, including growth and survival, apoptosis, invasion, and chemoresistance. Objectives: The present study aimed to investigate the potentiating effects of miR-129 on the chemosensitivity of ...  Read More

miR-214 sensitizes human colorectal cancer cells to doxorubicin by p53 targeting

Li Wang; Peng Jiang; Chenhui Qu; Xuefeng Li; Lei Wang; Chunhong Wei

Volume 22, Issue 12 , 2020

  Objectives: This study aimed to investigate the potential function of miR-214 in the apoptosis induction by targeting p53 in human colorectal cancer cells (CRC) in combination with doxorubicin (DOX). Methods: miR-214 mimics were transfected to HT-29 CRC cells. Following that, the transfected cells ...  Read More

Evaluation of Oncological Hyperthermia Centers and Turkey Modeling Oncological Hyperthermia Centers and Turkey Modeling

Fatih Goksel; Fatih Demircioglu

Volume 22, Issue 12 , 2020

  Introduction and Objectives: The latest technology and current treatments are used in the treatment of cancer in Turkey; however, oncological hyperthermia devices are currently not available. This study aimed to demonstrate the necessity of oncological hyperthermia devices in Turkey where cancer treatment ...  Read More

SiRNA-mediated lncRNA ANRIL knockdown enhances the sensitivity of gastric cancer cells to doxorubicin

Jiahai Chen; Xuejiang Dai; Hebin Yu; Fei Pe; Lina Chen

Volume 22, Issue 10 , 2020

  Background: Long non-coding RNAs (lncRNAs) play pivotal roles in carcinogenesis and the development of drug resistance in various malignancies. Objectives: The current study aimed to explore the impact of antisense non-coding RNA in the INK4 locus (ANRIL) silencing on proliferation and the sensitivity ...  Read More