Beneficial Effects of Intrathecal Injection of Methylprednisolone Against Spinal Cord Injury in Rats

Zhe Zhang; Cong Wang; Zhengmao Guan; Hui Ma

Volume 22, Issue 6 , 2020

  Background: High dose intravenous (i.t.) injection of methylprednisolone (MPSS) for spinal cord injury (SCI) is clinically contro- versial. Objectives: This study aimed to investigate whether i.t. MPSS would have a beneficial effect on SCI and whether or not it is a safe operation for SCI patients. Methods: ...  Read More

Combined Therapy Following Spinal Cord Injury: Synergistic Neuroprotective Effects of Ceftriaxone and N-acetylcysteine

Omid Salimi; Aliasghar Mohammadvand; Abbas Ebrahimi Kalan; Mohammad Charkhpour; Javad Mahmoudi; Bohlool Habibi Asl

Volume 22, Issue 4 , 2020

  Background: Spinal Cord Injury (SCI) is one of the leading causes of severe neurological deficits worldwide. The pathophysiology of SCI includes a primary injury followed by a cascade of secondary biochemical and cellular changes. Current pharmacological options are limited for significant recovery ...  Read More