Assessment of the Regulatory Effect of Novel Indole-Core-Based Compound on Apoptosis and Cell Survival of Acute Myeloid Leukemia Cell Line

Parisa Heydari; Mojgan Noroozi-Karimabad Noroozi-Karimabad; Zahra Sheikh rezaee; Ali Darekordi; Maryam Fekri Soofi Aadi; Ahmad Fatemi; Gholamhossein Hasanshahi

Volume 23, Issue 8 , 2021

Abstract
  Background: Heterocyclic compounds are generally introduced as important valuable sources of pharmacologically active compounds. Amongst these compounds, the indole is largely distributed within the bioactive molecules, containing antitumor agents. Due to their unique physiochemical and biological properties, ...  Read More

Effect of Melatonin on Reversing Multidrug Resistance by Targeting Phosphatase and Tensin Homolog in Leukemia Cancer Cells

Vahid Rameshknia; Moireh Movahhedi; Abbas Akhavan; Maryam Majidinia; Bahman Yousefi

Volume 23, Issue 7 , 2021

Abstract
  Background: Recently, melatonin has attracted massive attention due to its anticancer effect on various human malignancies. It has also been demonstrated that melatonin is useful in combating resistance against conventional chemotherapeutics. Objectives: This study aimed to evaluate melatonins effects ...  Read More